Literature summary for 2.7.1.91 extracted from

Limaye, V.; Vadas, M.A.; Pitson, S.M.; Gamble, J.R.
The effects of markedly raised intracellular sphingosine kinase-1 activity in endothelial cells (2009), Cell. Mol. Biol. Lett., 14, 411-423.

Cloned(Commentary)

Cloned (Comment)	Organism
overexpression of isoform Sk1 in HUVEC cell	Homo sapiens

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

General Information	Comment	Organism
physiological function	endothelial cells overepressing isoform Sk1 show reduced cell survival under conditions of stress, enhanced caspase-3 activity, cell cycle inhibition, and cell-cell junction disruption	Homo sapiens

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Release 2023.1 (January 2023)