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Literature summary for 2.7.1.91 extracted from

  • Akao, Y.; Banno, Y.; Nakagawa, Y.; Hasegawa, N.; Kim, T.J.; Murate, T.; Igarashi, Y.; Nozawa, Y.
    High expression of sphingosine kinase 1 and S1P receptors in chemotherapy-resistant prostate cancer PC3 cells and their camptothecin-induced up-regulation (2006), Biochem. Biophys. Res. Commun., 342, 1284-1290.
    View publication on PubMed
Search for more literature for 2.7.1.91

Activating Compound

Activating Compound Comment Organism Structure
camptothecin 0.003 mM camptothecin induces marked elevation of SPHK activity, reaching a maximal level with approximately 250% of the control untreated cells at 36 h Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
N,N-dimethylsphingosine 0.01 mM Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NYA1
-
-

Source Tissue

Source Tissue Comment Organism Textmining
PC-3 cell
-
 Homo sapiens
-
prostate cancer cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + sphingosine
-
 Homo sapiens ADP + sphingosine 1-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
sphinganine kinase
-
 Homo sapiens
SPHK1
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens