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Literature summary for 2.7.1.82 extracted from

  • Kuan, C.S.; See Too, W.C.; Few, L.L.
    Sp1 and Sp3 are the transcription activators of human ek1 promoter in TSA-treated human colon carcinoma cells (2016), PLoS ONE, 11, e0147886.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
gene eki1, a Sp site at position (-40/-31) is essential for the basal transcription of this gene, quantitative real-time PCR transcription analysis of ek1 mRNA, Identification of important regulatory regions in the ek1 gene promoter by analysis of 4 promoter constructs, trichostatin A activates basal ek1 promoter activity via Sp(-40/-31) site Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9HBU6 gene EKI1
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Source Tissue

Source Tissue Comment Organism Textmining
colon carcinoma cell
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 Homo sapiens
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HCT-116 cell
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 Homo sapiens
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Hep-G2 cell
-
 Homo sapiens
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MCF-7 cell
-
 Homo sapiens
-

Expression

Organism Comment Expression
Homo sapiens treatment of HCT-116 cells with trichostatin A (TSA), a histone deacetylase inhibitor, significantly upregulates the eki1 promoter activity through the Sp(-40/-31) site and increases the endogenous expression of gene eki1. Trichostatin A increases the binding of Sp1, Sp3 and RNA polymerase II to the ek1 promoter in HCT116 cells, molecular mechanism, overview. The effect of TSA on ek1 promoter activity is cell-line specific as TSA treatment does not affect ek1 promoter activity in Hep-G2 cells up

General Information

General Information Comment Organism
metabolism a key enzyme in cellular phospholipid synthesis Homo sapiens