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Literature summary for 2.7.1.78 extracted from

  • Tsukada, K.; Matsumoto, Y.; Shimada, M.
    Linker region is required for efficient nuclear localization of polynucleotide kinase phosphatase (2020), PLoS ONE, 15, e0239404 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.78

Protein Variants

Protein Variants Comment Organism
K138A/R35A the mutant shows impaired nuclear localization as compared to the wild type enzyme Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 5'-dephospho-DNA Homo sapiens
-
 ADP + 5'-phospho-DNA
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
 Homo sapiens
-
U2-OS cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 5'-dephospho-DNA
-
 Homo sapiens ADP + 5'-phospho-DNA
-
 ?

Synonyms

Synonyms Comment Organism
PNKP
-
 Homo sapiens
polynucleotide kinase phosphatase
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function polynucleotide kinase phosphatase is a DNA repair factor with dual enzymatic functions, i.e., phosphorylation of 5'-end and dephosphorylation of 3'-end, which are prerequisites for DNA ligation and, thus, is involved in multiple DNA repair pathways, i.e., base excision repair, single-strand break repair and double-strand break repair through nonhomologous end joining Homo sapiens