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Literature summary for 2.7.1.76 extracted from

  • Serra, I.; Ubiali, D.; Piskur, J.; Munch-Petersen, B.; Bavaro, T.; Terreni, M.
    Immobilization of deoxyadenosine kinase from Dictyostelium discoideum (DddAK) and its application in the 5'-phosphorylation of arabinosyladenine and arabinosyl-2-fluoroadenine (2017), ChemistrySelect, 2, 5403-5408 .
No PubMed abstract available
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General Stability

General Stability Organism
immobilization by ionic interaction on an aminated epoxy-functionalized support (Sepabeads) enhances the stability of the enzyme at pH 10 and to a lesser extent at 45°C Dictyostelium discoideum

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ mM used in assay conditions Dictyostelium discoideum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 2'-deoxyadenosine Dictyostelium discoideum
-
 ADP + dAMP
-
 ?

Organism

Organism UniProt Comment Textmining
Dictyostelium discoideum
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 2'-deoxyadenosine
-
 Dictyostelium discoideum ADP + dAMP
-
 ?
ATP + arabinosyl-2-fluoroadenine
-
 Dictyostelium discoideum ADP + arabinosyl-2-fluoroadenine 5'-phosphate
-
 ?
ATP + arabinosyladenine
-
 Dictyostelium discoideum ADP + arabinosyladenine 5'-phosphate
-
 ?
ATP + fludarabine
-
 Dictyostelium discoideum ADP + fludarabine 5'-phosphate
-
 ?
ATP + vidarabine
-
 Dictyostelium discoideum ADP + vidarabine 5'-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
dAK
-
 Dictyostelium discoideum
deoxyadenosine kinase
-
 Dictyostelium discoideum

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
25
-
 at pH 10 and 25°C, the soluble enzyme maintains 50% of the starting activity upon about 20 h incubation Dictyostelium discoideum

pH Stability

pH Stability pH Stability Maximum Comment Organism
10
-
 at pH 10 and 25°C, the soluble enzyme maintains 50% of the starting activity upon about 20 h incubation Dictyostelium discoideum