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Literature summary for 2.7.1.76 extracted from

  • Deibler, R.D.; Reznik, R.B.; Ives, D.H.
    Deoxynucleoside kinases from Lactobacilli. Separate interacting sites for deoxycytidine and deoxyadenosine (1977), J. Biol. Chem., 252, 8240-8244.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
2'-O-Cyclocytidine activation Lactobacillus acidophilus
5-Fluoro-2'-deoxycytidine 0.4 mM, 275% activation of deoxyadenosine phosphorylation, half-maximal activation at 0.028 mM Lactobacillus acidophilus
cytosine arabinoside activation Lactobacillus acidophilus
deoxycytidine 30 mM, 584% activation of deoxyadenosine phosphorylation, half-maximal activation at 0.1 mM Lactobacillus acidophilus
deoxycytidine monophosphate 10 mM, 409% activation of deoxyadenosine phosphorylation, half-maximal activation at 1.6 mM Lactobacillus acidophilus
deoxyguanosine 5 mM, 330% activation of deoxyadenosine phosphorylation, half-maximal activation at 2.2 mM Lactobacillus acidophilus

Inhibitors

Inhibitors Comment Organism Structure
adenine arabinoside
-
Lactobacillus acidophilus
adenosine
-
Lactobacillus acidophilus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information kinetic study Lactobacillus acidophilus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required for activity Lactobacillus acidophilus

Organism

Organism UniProt Comment Textmining
Lactobacillus acidophilus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
ATP + 2'-deoxyadenosine = ADP + dAMP random sequential substrate addition Lactobacillus acidophilus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + deoxyadenosine enzyme bears two separate but interacting active sites for deoxyadenosine and deoxycytidine kinase activity Lactobacillus acidophilus ADP + dAMP
-
?
ATP + deoxycytidine
-
Lactobacillus acidophilus ADP + dCMP
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
20
-
assay at Lactobacillus acidophilus