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Literature summary for 2.7.1.74 extracted from

  • Ohmine, K.; Kawaguchi, K.; Ohtsuki, S.; Motoi, F.; Egawa, S.; Unno, M.; Terasaki, T.
    Attenuation of phosphorylation by deoxycytidine kinase is key to acquired gemcitabine resistance in a pancreatic cancer cell line: targeted proteomic and metabolomic analyses in PK9 cells (2012), Pharm. Res., 29, 2006-2016.
    View publication on PubMed
Search for more literature for 2.7.1.74

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 2',2'-difluorodeoxycytidine Homo sapiens i.e. gemcitabine, transport and metabolism in vivo, overview ADP + 2',2'-difluorodeoxycytidine monophosphate
-
 ?
ATP + deoxycytidine Homo sapiens
-
 ADP + dCMP
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
pancreatic cancer cell
-
 Homo sapiens
-
PK-9 cell
-
 Homo sapiens
-
RPK-9 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 2',2'-difluorodeoxycytidine i.e. gemcitabine Homo sapiens ADP + 2',2'-difluorodeoxycytidine monophosphate
-
 ?
ATP + 2',2'-difluorodeoxycytidine i.e. gemcitabine, transport and metabolism in vivo, overview Homo sapiens ADP + 2',2'-difluorodeoxycytidine monophosphate
-
 ?
ATP + deoxycytidine
-
 Homo sapiens ADP + dCMP
-
 ?

Synonyms

Synonyms Comment Organism
dCK
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction deoxxycytidine kinase inhibition causes gemcitabine resistance, overview Homo sapiens
metabolism 2',2'-difluorodeoxycytidine, i.e. gemcitabine, is phosphorylated intracellularly via multiple steps, and the triphosphate inhibits DNA synthesis by interfering with incorporation of endogenous dCTP into DNA, deocycytidine kinase catalyzes the first phosphorylation step, overview Homo sapiens