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Literature summary for 2.7.1.74 extracted from

  • Mirzaee, S.; Eriksson, S.; Albertioni, F.
    Differences in cytosolic and mitochondrial 5'-nucleotidase and deoxynucleoside kinase activities in Sprague-Dawley rat and CD-1 mouse tissues: Implication for the toxicity of nucleoside analogs in animal models (2010), Toxicology, 267, 159-164.
    View publication on PubMed
Search for more literature for 2.7.1.74

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Mus musculus 5829
-
cytosol
-
 Rattus norvegicus 5829
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Mus musculus
Mg2+ required Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + deoxycytidine Mus musculus
-
 ADP + dCMP
-
 ?
ATP + deoxycytidine Rattus norvegicus
-
 ADP + dCMP
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adipose tissue
-
 Mus musculus
-
adipose tissue
-
 Rattus norvegicus
-
biceps
-
 Mus musculus
-
biceps
-
 Rattus norvegicus
-
brain
-
 Mus musculus
-
brain
-
 Rattus norvegicus
-
brown adipose tissue
-
 Mus musculus
-
brown adipose tissue
-
 Rattus norvegicus
-
brown fat
-
 Mus musculus
-
brown fat
-
 Rattus norvegicus
-
diaphragm
-
 Mus musculus
-
diaphragm
-
 Rattus norvegicus
-
heart
-
 Mus musculus
-
heart
-
 Rattus norvegicus
-
heart low enzyme activity Mus musculus
-
heart low enzyme activity Rattus norvegicus
-
kidney
-
 Mus musculus
-
kidney
-
 Rattus norvegicus
-
liver
-
 Mus musculus
-
liver
-
 Rattus norvegicus
-
lung
-
 Mus musculus
-
lung
-
 Rattus norvegicus
-
additional information enzyme activity tissue distribution analysis, overview Mus musculus
-
additional information enzyme activity tissue distribution analysis, overview Rattus norvegicus
-
pancreas
-
 Mus musculus
-
pancreas
-
 Rattus norvegicus
-
semitendinosus
-
 Mus musculus
-
semitendinosus
-
 Rattus norvegicus
-
skeletal muscle
-
 Mus musculus
-
skeletal muscle
-
 Rattus norvegicus
-
skeletal muscle low enzyme activity Mus musculus
-
skeletal muscle low enzyme activity Rattus norvegicus
-
skeletal muscle vastus Mus musculus
-
skeletal muscle vastus Rattus norvegicus
-
spleen
-
 Mus musculus
-
spleen
-
 Rattus norvegicus
-
testis
-
 Mus musculus
-
testis
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 2'-deoxycytidine
-
 Mus musculus ADP + 2'-deoxycytidine 5'-phosphate
-
 ?
ATP + 2'-deoxycytidine
-
 Rattus norvegicus ADP + 2'-deoxycytidine 5'-phosphate
-
 ?
ATP + deoxycytidine
-
 Mus musculus ADP + dCMP
-
 ?
ATP + deoxycytidine
-
 Rattus norvegicus ADP + dCMP
-
 ?

Synonyms

Synonyms Comment Organism
dCK
-
 Mus musculus
dCK
-
 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Mus musculus
37
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.6
-
 assay at Mus musculus
7.6
-
 assay at Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus
ATP
-
 Rattus norvegicus

General Information

General Information Comment Organism
physiological function cytosolic and mitochondrial deoxynucleoside kinases, as well as 5'-deoxynucleotidases, control intracellular and intramitochondrial phosphorylation of natural nucleotides and nucleoside analogs used in antiviral and cancer chemotherapy, overview Mus musculus
physiological function cytosolic and mitochondrial deoxynucleoside kinases, as well as 5'-deoxynucleotidases, control intracellular and intramitochondrial phosphorylation of natural nucleotides and nucleoside analogs used in antiviral and cancer chemotherapy, overview Rattus norvegicus