Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.1.74 extracted from

  • Joachims, M.L.; Marble, P.; Knott-Craig, C.; Pastuszko, P.; Blackburn, M.R.; Thompson, L.F.
    Inhibition of deoxynucleoside kinases in human thymocytes prevents dATP accumulation and induction of apoptosis (2008), Nucleosides Nucleotides Nucleic Acids, 27, 816-820.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.74

Application

Application Comment Organism
medicine thymocytes lacking adenosine deaminase activity accumulate intracellular dATP and undergo apoptosis. Inhibition of deoxycytidine kinase prevents the accumulation of dATP and induction of apoptosis to a large degree, inhibition of both deoxycytidine kinase and adenosine kinase completely abrogates accumulation of dATP and significantly reduces the induction of apoptosis Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2'-deoxycytidine
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
thymocyte
-
 Homo sapiens
-
thymocyte suspension culture Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 2'-deoxycytidine
-
 Homo sapiens ADP + 2'-deoxycytidine 5'-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
dCK
-
 Homo sapiens
deoxycytidine kinase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction dCK inhibition reduces the induction of apoptosis in thymocytes Homo sapiens