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Literature summary for 2.7.1.74 extracted from

  • Bierau, J.; van Gennip, A.H.; Leen, R.; Meinsma, R.; Caron, H.N.; van Kuilenburg, A.B.
    Cyclopentenyl cytosine-induced activation of deoxycytidine kinase increases gemcitabine anabolism and cytotoxicity in neuroblastoma (2006), Cancer Chemother. Pharmacol., 57, 105-113.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information enzyme protein level increases when cells are incubated with cyclopentenyl cytosine Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NTP + 2',2'-difluorodeoxycytidine Homo sapiens i.e. gemcitabine, rate limiting enzyme in the activation of the pharmaceutically relevant substrate which is commonly used in the treatment of solid malignant tumors NDP + 2',2'-difluorodeoxycytidine 5'-phosphate
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Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
SK-N-BE(2) cell
-
Homo sapiens
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SK-N-SH cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NTP + 2',2'-difluorodeoxycytidine i.e. gemcitabine, rate limiting enzyme in the activation of the pharmaceutically relevant substrate which is commonly used in the treatment of solid malignant tumors Homo sapiens NDP + 2',2'-difluorodeoxycytidine 5'-phosphate
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?

Synonyms

Synonyms Comment Organism
dCK
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Homo sapiens