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Literature summary for 2.7.1.74 extracted from

  • Hughes, T.L.; Hahn, T.M.; Reynolds, K.K.; Shewach, D.S.
    Kinetic analysis of human deoxycytidine kinase with the true phosphate donor uridine triphosphate (1997), Biochemistry, 36, 7540-7547.
    View publication on PubMed
Search for more literature for 2.7.1.74

Activating Compound

Activating Compound Comment Organism Structure
ATP substrate activation, at high concentrations of deoxycytidine Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
dCMP
-
 Homo sapiens
dCTP
-
 Homo sapiens
deoxycytidine at concentrations greater than 0.003 mM, UTP as substrate, noncompetitive Homo sapiens
UDP
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0005
-
 UTP cosubstrate 2'-deoxycytidine, 37°C, pH 7.4 Homo sapiens
0.0009
-
 GTP cosubstrate 2'-deoxycytidine, 37°C, pH 7.4 Homo sapiens
0.001
-
 ATP cosubstrate 2'-deoxycytidine, 37°C, pH 7.4 Homo sapiens
0.001
-
 dTTP cosubstrate 2'-deoxycytidine, 37°C, pH 7.4 Homo sapiens
0.0013
-
 CTP cosubstrate 2'-deoxycytidine, 37°C, pH 7.4 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Reaction

Reaction Comment Organism Reaction ID
NTP + deoxycytidine = NDP + dCMP mechanism Homo sapiens
a
NTP + deoxycytidine = NDP + dCMP ordered A-B random B-Q reaction sequence Homo sapiens
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CTP + 2'-deoxycytidine
-
 Homo sapiens CDP + 2'-deoxy-CMP
-
 ?
dTTP + 2'-deoxycytidine
-
 Homo sapiens dTDP + 2'-deoxy-CMP
-
 ?
GTP + 2'-deoxycytidine
-
 Homo sapiens GDP + 2'-deoxy-CMP
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0004
-
 UDP cosubstrate UTP, 37°C, pH 7.4 Homo sapiens
0.0015
-
 dCMP cosubstrate UTP, 37°C, pH 7.4 Homo sapiens
0.0069
-
 UDP cosubstrate deoxycytidine, 37°C, pH 7.4 Homo sapiens
0.022
-
 dCMP cosubstrate deoxycytidine, 37°C, pH 7.4 Homo sapiens