Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21(DE3) cells | Mycobacterium tuberculosis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2E)-3-(4-hydroxy-3-methoxyphenyl)-2-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]prop-2-enenitrile | uncompetitive inhibition towards shikimate and competitive inhibition towards ATP | Mycobacterium tuberculosis | |
(2E)-N-(3-acetylphenyl)-3-(4-nitrophenyl)prop-2-enamide | non-competitive inhibition towards shikimate and competitive inhibition towards ATP | Mycobacterium tuberculosis | |
(2E,5Z)-5-[4-(dimethylamino)benzylidene]-2-(2-oxo-2-phenylethylidene)-1,3-thiazolidin-4-one | uncompetitive inhibition towards shikimate and competitive inhibition towards ATP | Mycobacterium tuberculosis | |
2-[(4-aminophenyl)amino]-3-(piperidin-1-yl)naphthalene-1,4-dione | non-competitive inhibition towards shikimate and competitive inhibition towards ATP | Mycobacterium tuberculosis | |
5-[[(5-chloro-2-hydroxyphenyl)amino]methylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione | uncompetitive inhibition towards shikimate and competitive inhibition towards ATP | Mycobacterium tuberculosis |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.1306 | - |
ATP | at pH 7.6 and 25°C | Mycobacterium tuberculosis | |
0.3994 | - |
shikimate | at pH 7.6 and 25°C | Mycobacterium tuberculosis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + shikimate | Mycobacterium tuberculosis | - |
ADP + 3-phosphoshikimate | - |
? | |
ATP + shikimate | Mycobacterium tuberculosis H37Rv | - |
ADP + 3-phosphoshikimate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | - |
- |
- |
Mycobacterium tuberculosis H37Rv | - |
- |
- |
Purification (Comment) | Organism |
---|---|
Ni-NTA column chromatography | Mycobacterium tuberculosis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + shikimate | - |
Mycobacterium tuberculosis | ADP + 3-phosphoshikimate | - |
? | |
ATP + shikimate | - |
Mycobacterium tuberculosis H37Rv | ADP + 3-phosphoshikimate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AroK | - |
Mycobacterium tuberculosis |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0051 | - |
at pH 7.6 and 25°C | Mycobacterium tuberculosis | 5-[[(5-chloro-2-hydroxyphenyl)amino]methylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione | |
0.00675 | - |
at pH 7.6 and 25°C | Mycobacterium tuberculosis | 2-[(4-aminophenyl)amino]-3-(piperidin-1-yl)naphthalene-1,4-dione | |
0.00858 | - |
at pH 7.6 and 25°C | Mycobacterium tuberculosis | (2E)-3-(4-hydroxy-3-methoxyphenyl)-2-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]prop-2-enenitrile | |
0.00875 | - |
at pH 7.6 and 25°C | Mycobacterium tuberculosis | (2E)-N-(3-acetylphenyl)-3-(4-nitrophenyl)prop-2-enamide | |
0.00968 | - |
at pH 7.6 and 25°C | Mycobacterium tuberculosis | (2E,5Z)-5-[4-(dimethylamino)benzylidene]-2-(2-oxo-2-phenylethylidene)-1,3-thiazolidin-4-one |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
17 | - |
shikimate | at pH 7.6 and 25°C | Mycobacterium tuberculosis | |
60 | - |
ATP | at pH 7.6 and 25°C | Mycobacterium tuberculosis |