Any feedback?
Literature summary for 2.7.1.71 extracted from
- Shikimate kinase: a potential target for development of novel antitubercular agents (2007), Curr. Drug Targets, 8, 459-468.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli strain BL21(DE3) | Mycobacterium tuberculosis |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
- |
Dickeya chrysanthemi |
| hanging drop vapour diffusion method | Mycobacterium tuberculosis |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| K15M | no detectable enzyme activity | Dickeya chrysanthemi |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.2 | - |
shikimate | - |
Escherichia coli |  |
| 0.41 | - |
shikimate | - |
Mycobacterium tuberculosis | |
| 0.62 | - |
ATP | - |
Dickeya chrysanthemi | |
| 20 | - |
shikimate | - |
Escherichia coli | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required in complex with ATP | Escherichia coli | |
| Mg2+ | required in complex with ATP | Mycobacterium tuberculosis | |
| Mg2+ | required in complex with ATP | Dickeya chrysanthemi | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 18580 | - |
calculated from amino acid sequence | Mycobacterium tuberculosis |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Dickeya chrysanthemi | - |
- |
- |
| Escherichia coli | - |
- |
- |
| Mycobacterium tuberculosis | - |
- |
- |
| Mycobacterium tuberculosis H37Rv | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + shikimate | - |
Escherichia coli | ADP + shikimate 3-phosphate | - |
? | |
| ATP + shikimate | - |
Mycobacterium tuberculosis | ADP + shikimate 3-phosphate | - |
? | |
| ATP + shikimate | - |
Dickeya chrysanthemi | ADP + shikimate 3-phosphate | - |
? | |
| ATP + shikimate | - |
Mycobacterium tuberculosis H37Rv | ADP + shikimate 3-phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Rv2539c | - |
Mycobacterium tuberculosis |
| SK I | - |
Escherichia coli |
| SK I | - |
Mycobacterium tuberculosis |
| SK II | - |
Escherichia coli |
| type I shikimate kinase, aroK-encoded | - |
Mycobacterium tuberculosis |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Escherichia coli | |
| ATP | - |
Mycobacterium tuberculosis | |
| ATP | - |
Dickeya chrysanthemi | |
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Release 2023.1 (January 2023)
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