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Literature summary for 2.7.1.7 extracted from

  • Coulombel, C.; Foglietti, M.J.; Percheron, F.
    Identification and kinetic studies of an inducible mannokinase from a Streptomyces strain (1982), Biochim. Biophys. Acta, 706, 117-122.
    View publication on PubMed
Search for more literature for 2.7.1.7

Inhibitors

Inhibitors Comment Organism Structure
D-mannose 6-phosphate competitive versus mannose and noncompetitive versus MgATP2- Streptomyces sp.
MgADP-
-
 Streptomyces sp.

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.33
-
 D-mannose pH 8.4, 37°C Streptomyces sp.
1.1
-
 ATP pH 8.4, 37°C Streptomyces sp.
1.1
-
 ATP ATP in form of MgATP2- Streptomyces sp.

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Streptomyces sp.
Mg2+ optimal Mg2+/ATP ratio is 1 Streptomyces sp.

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
50000
-
 gel filtration Streptomyces sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + D-mannose Streptomyces sp. inducible enzyme ADP + D-mannose 6-phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Streptomyces sp.
-
-
-

Reaction

Reaction Comment Organism Reaction ID
ATP + D-mannose = ADP + D-mannose 6-phosphate sequential bi-bi mechanism with two dead-end ternary complexes Streptomyces sp.
a

Source Tissue

Source Tissue Comment Organism Textmining
cell culture grown on D-mannose or beta-D-mannan Streptomyces sp.
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + D-fructose no activity Streptomyces sp. ADP + D-fructose 6-phosphate
-
 ?
ATP + D-mannose inducible enzyme Streptomyces sp. ADP + D-mannose 6-phosphate
-
 ?
ATP + D-mannose highly specific for D-mannose Streptomyces sp. ADP + mannose 6-phosphate
-
 ?
CTP + D-mannose no activity Streptomyces sp. CDP + D-mannose 6-phosphate
-
 ?
GTP + D-mannose 10% of the activity with ATP Streptomyces sp. GDP + D-mannose 6-phosphate
-
 ?
ITP + D-mannose 15% of the activity with ATP Streptomyces sp. IDP + D-mannose 6-phosphate
-
 ?
UTP + D-mannose no activity Streptomyces sp. UDP + D-mannose 6-phosphate
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.5
-
 MgADP- pH 8.4, 37°C, competitive versus MgAtP2- Streptomyces sp.
1.1
-
 MgADP- pH 8.4, 37°C, noncompetitive versus mannose Streptomyces sp.
12.5
-
 mannose 6-phosphate pH 8.4, 37°C, noncompetitive versus MgATP2- Streptomyces sp.
22.5
-
 mannose 6-phosphate pH 8.4, 37°C, competitive versus mannose Streptomyces sp.