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Literature summary for 2.7.1.68 extracted from
- Type I gamma phosphatidylinositol phosphate 5-kinase i5 controls the ubiquitination and degradation of the tumor suppressor mitogen-inducible gene 6 (2016), J. Biol. Chem., 291, 21461-21473 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed as His6-tagged protein in Escherichia coli BL21(DE3) cells | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | Homo sapiens | - |
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| Ni-NTA agarose column chromatography | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| MDA-MB-231 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
Homo sapiens | ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 95000, isoform PIPKIgammai5, SDS-PAGE | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PIPKIgammai5 | - |
Homo sapiens |
| type I gamma phosphatidylinositol phosphate 5-kinase i5 | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | knockdown of isoform PIPKIgammai5 leads to the loss of mitogen-inducible gene 6 expression, which dramatically enhances and prolongs epidermal growth factor receptor-mediated cell signaling | Homo sapiens |
| physiological function | isoform PIPKIgammai5 controls Mig6 ubiquitination and degradation. Isoform PIPKIgammai5, the E3 ubiquitin ligase neuronal precursor cell-expressed developmentally down-regulated 4-1, and mitogen-inducible gene 6 form a molecular nexus that controls epidermal growth factor receptor activation and downstream signalling | Homo sapiens |
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Release 2023.1 (January 2023)
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