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Literature summary for 2.7.1.68 extracted from

  • Kubo, T.; Ding, W.G.; Toyoda, F.; Fujii, Y.; Omatsu-Kanbe, M.; Matsuura, H.
    Phosphatidylinositol4-phosphate 5-kinase prevents the decrease in the HERG potassium current induced by Gq protein-coupled receptor stimulation (2015), J. Pharmacol. Sci., 127, 127-134.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in CHO cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
K138A inactive Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Wortmannin
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate Homo sapiens
-
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
Homo sapiens ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
?

Synonyms

Synonyms Comment Organism
phosphatidylinositol4-phosphate 5-kinase
-
Homo sapiens
PI(4)P5-K
-
Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme prevents the decrease in the HRG (human ether-a-go-go-related gene) potassium current induced by Gq protein-coupled receptor stimulation Homo sapiens