Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.1.68 extracted from

  • Choi, S.; Thapa, N.; Hedman, A.C.; Li, Z.; Sacks, D.B.; Anderson, R.A.
    IQGAP1 is a novel phosphatidylinositol 4,5 bisphosphate effector in regulation of directional cell migration (2013), EMBO J., 32, 2617-2630.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.68

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate Homo sapiens
-
 ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O60331
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
 Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-
MDA-MB-231 cell
-
 Homo sapiens
-
MDCK cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 Homo sapiens ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?

Synonyms

Synonyms Comment Organism
PIPKIgamma
-
 Homo sapiens
type Igamma phosphatidylinositol 4-phosphate 5-kinase
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme interacts with the cytoskeleton regulator IQGAP1 and modulates IQ motif containing GTPase activating protein 1 (IQGAP1) function in migration. The enzyme is required for IQGAP1 recruitment to the leading edge membrane in response to integrin or growth factor receptor activation Homo sapiens