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Literature summary for 2.7.1.68 extracted from

  • Wong, K.W.; Isberg, R.R.
    Arf6 and phosphoinositol-4-phosphate-5-kinase activities permit bypass of the Rac1 requirement for beta1 integrin-mediated bacterial uptake (2003), J. Exp. Med., 198, 603-614.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.68

Activating Compound

Activating Compound Comment Organism Structure
Arf6 activates the enzyme via binding of small GTPase Rac1, regulatory function, mutant Arf6 N121I is defective for nucleotide binding, mutant Q67L is similarly active as the wild-type Arf6 Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
coexpression of wild-type HA-tagged isozyme alpha or HA-tagged isozyme alpha mutant D227A with HA-tagged Arf6 or HA-tagged Arf6 mutant N121I in COS-1 cells Mus musculus

Protein Variants

Protein Variants Comment Organism
D227A site-directed muatgenesis, inactive mutant Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Mus musculus 5829
-
plasma membrane
-
 Mus musculus 5886
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate Mus musculus the enzyme activity is regulated by Arf6 activation ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?
additional information Mus musculus 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate production by the enzyme, presence of Arf6, and binding of the bacterial invasin protein to beta1 integrin receptors are required for the small GTPase Rac1-dependent pathway, which is activated for efficient entry of the bacterium Yersinia pseudotuberculosis, into mammalian cells, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 Mus musculus ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate the enzyme activity is regulated by Arf6 activation Mus musculus ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?
additional information 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate production by the enzyme, presence of Arf6, and binding of the bacterial invasin protein to beta1 integrin receptors are required for the small GTPase Rac1-dependent pathway, which is activated for efficient entry of the bacterium Yersinia pseudotuberculosis, into mammalian cells, overview Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
phosphoinositol-4-phosphate-5-kinase
-
 Mus musculus
PIP5K
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus