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Literature summary for 2.7.1.68 extracted from

  • Coppolino, M.G.; Dierckman, R.; Loijens, J.; Collins, R.F.; Pouladi, M.; Jongstra-Bilen, J.; Schreiber, A.D.; Trimble, W.S.; Anderson, R.; Grinstein, S.
    Inhibition of phosphatidylinositol-4-phosphate 5-kinase Ialpha impairs localized actin remodeling and suppresses phagocytosis (2002), J. Biol. Chem., 277, 43849-43857.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression of mutant enzymes K181A, D309N, D309N/R429Q and R427Q in Escherichia coli, expression of mutant enzymes in human MG-63 osteosarcoma cells Mus musculus

Protein Variants

Protein Variants Comment Organism
D309N greatly reduced kinase activity towards 1-phosphatidyl-1D-myo-inositol 4-phosphate Mus musculus
D309N/R427Q greatly reduced kinase activity towards 1-phosphatidyl-1D-myo-inositol 4-phosphate Mus musculus
K181A greatly reduced kinase activity towards 1-phosphatidyl-1D-myo-inositol 4-phosphate Mus musculus
R427Q greatly reduced kinase activity towards 1-phosphatidyl-1D-myo-inositol 4-phosphate Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Mus musculus 5737
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate Mus musculus PIPKIalpha activity is involved in the actin remodeling that is a prerequisite for efficient phagocytosis. PIPKIalpha appears to contribute to the transient changes in 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate levels that are associated with, and likely required for, the recruitment and regulation of actin-modulating proteins ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
hematopoietic cell line
-
Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
Mus musculus ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate PIPKIalpha activity is involved in the actin remodeling that is a prerequisite for efficient phagocytosis. PIPKIalpha appears to contribute to the transient changes in 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate levels that are associated with, and likely required for, the recruitment and regulation of actin-modulating proteins Mus musculus ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
?