Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Acetylcholine | 0.01 mM or 0.1 mM, each in presence of 0.1 mM eserine, stimulates the enzyme in homogenates by 30-40% | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | product inhibition | Rattus norvegicus | |
Ca2+ | inhibits in presence of optimal Mg2+ concentrations | Rattus norvegicus | |
cysteine | 1 mM, 49% inhibition | Rattus norvegicus | |
GSSG | 0.1 mM, 17% inhibition | Rattus norvegicus | |
NEM | 1 mM, 26% inhibition | Rattus norvegicus | |
PCMB | 0.1 mM, complete inhibition | Rattus norvegicus | |
Triton X-100 | 0.5-3.0% w/v, 40% inhibition | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.25 | - |
1-phosphatidyl-1D-myo-inositol 4-phosphate | pH 7.4, 37°C | Rattus norvegicus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | activates to a smaller extent than Mg2+ | Rattus norvegicus | |
Co2+ | activates to a smaller extent than Mg2+ | Rattus norvegicus | |
Mg2+ | activates | Rattus norvegicus | |
Mn2+ | activates to a smaller extent than Mg2+ | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
Rattus norvegicus | ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.3 | - |
- |
Rattus norvegicus |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
6.1 | 7.9 | pH 6.1: about 85% of maximal activity, pH 7.9: about 85% of maximal activity | Rattus norvegicus |