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Literature summary for 2.7.1.68 extracted from

  • Kai, M.; Salway, J.G.; Hawthorne, J.N.
    The diphosphoinositide kinase of rat brain (1968), Biochem. J., 106, 791-801.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
Acetylcholine 0.01 mM or 0.1 mM, each in presence of 0.1 mM eserine, stimulates the enzyme in homogenates by 30-40% Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate product inhibition Rattus norvegicus
Ca2+ inhibits in presence of optimal Mg2+ concentrations Rattus norvegicus
cysteine 1 mM, 49% inhibition Rattus norvegicus
GSSG 0.1 mM, 17% inhibition Rattus norvegicus
NEM 1 mM, 26% inhibition Rattus norvegicus
PCMB 0.1 mM, complete inhibition Rattus norvegicus
Triton X-100 0.5-3.0% w/v, 40% inhibition Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.25
-
1-phosphatidyl-1D-myo-inositol 4-phosphate pH 7.4, 37°C Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ activates to a smaller extent than Mg2+ Rattus norvegicus
Co2+ activates to a smaller extent than Mg2+ Rattus norvegicus
Mg2+ activates Rattus norvegicus
Mn2+ activates to a smaller extent than Mg2+ Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
Rattus norvegicus ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.3
-
-
Rattus norvegicus

pH Range

pH Minimum pH Maximum Comment Organism
6.1 7.9 pH 6.1: about 85% of maximal activity, pH 7.9: about 85% of maximal activity Rattus norvegicus