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Literature summary for 2.7.1.68 extracted from

  • Cooper, P.H.; Hawthorne, J.N.
    Phosphatidylinositol kinase and diphosphoinositide kinase of rat kidney cortex: properties and subcellular localization (1976), Biochem. J., 160, 97-105.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
ATP above 4 mM Rattus norvegicus
cetyltrimethylammonium bromide
-
 Rattus norvegicus
Cutsum
-
 Rattus norvegicus
EDTA slight inhibition between 0.5-5 mM Rattus norvegicus
sodium deoxycholate
-
 Rattus norvegicus
Triton X-100
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus
-
 Rattus norvegicus 5794
-

Metals/Ions

Metals/Ions Comment Organism Structure
Co2+ 2 mM, activates Rattus norvegicus
Fe2+ 2 mM, slight inhibition Rattus norvegicus
Mg2+ activates Rattus norvegicus
Mg2+ 2 mM, dependent on Rattus norvegicus
Mn2+ 2 mM, activates Rattus norvegicus
Zn2+ 2 mM, slight inhibition Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney cortex Rattus norvegicus
-
renal cortex
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 Rattus norvegicus ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5
-
-
 Rattus norvegicus

pH Range

pH Minimum pH Maximum Comment Organism
5 8 pH 5.0: about 65% of maximal activity, pH 8.0: about 75% of maximal activity Rattus norvegicus