Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Arabidopsis thaliana |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-phosphatidyl-1D-myo-inositol | Arabidopsis thaliana | - |
ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Arabidopsis thaliana | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cell suspension culture | - |
Arabidopsis thaliana | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-phosphatidyl-1D-myo-inositol | - |
Arabidopsis thaliana | ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AtPI4KIIIalpha1 | - |
Arabidopsis thaliana |
AtPI4KIIIbeta1 | - |
Arabidopsis thaliana |
AtPI4KIIIbeta2 | - |
Arabidopsis thaliana |
phosphatidylinositol 4-kinase | - |
Arabidopsis thaliana |
PI4K | - |
Arabidopsis thaliana |
type-II PI4K | - |
Arabidopsis thaliana |
type-III phosphatidylinositol 4-kinase beta1 | - |
Arabidopsis thaliana |
type-III phosphatidylinositol 4-kinase beta2 | - |
Arabidopsis thaliana |
type-III PI4K | - |
Arabidopsis thaliana |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Arabidopsis thaliana |
General Information | Comment | Organism |
---|---|---|
malfunction | phosphatidic acid resulting from the phosphoinositide-dependent phospholipase C pathway is significantly lowered in a pi4kIIIbeta1beta2 double mutant exposed to cold stress, phenotype, overview. The root growth in the double mutant is 5fold reduced at 12°C | Arabidopsis thaliana |
metabolism | the enzyme catalyzes the first step in generating the phosphoinositides hydrolyzed by phosphoinositide-dependent phospholipase C, EC 3.1.4.11, that produces diacylglycerol which can be phosphorylated to phosphatidic acid. Type-III PIK activity is upstream of the phosphoinositide-dependent phospholipase C activity | Arabidopsis thaliana |
physiological function | Arabidopsis thaliana type-III phosphatidylinositol 4-kinases beta1 and beta2 are upstream of the phospholipase C pathway triggered by cold exposure, overview. De novo synthesis of 1-phosphatidyl-1D-myo-inositol 4-phosphate by PI4Ks occurs in parallel to phosphoinositide-dependent phospholipase C activation | Arabidopsis thaliana |