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Literature summary for 2.7.1.67 extracted from

  • Banerji, S.; Ngo, M.; Lane, C.F.; Robinson, C.A.; Minogue, S.; Ridgway, N.D.
    Oxysterol binding protein-dependent activation of sphingomyelin synthesis in the Golgi apparatus requires phosphatidylinositol 4-kinase IIalpha (2010), Mol. Biol. Cell, 21, 4141-4150.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.67

Activating Compound

Activating Compound Comment Organism Structure
25-hydroxycholesterol activates Golgi/endosome-associated PI4K activity, PI4K activation by 25-hydroxycholesterol is dependent on oxysterol binding protein, overview Cricetulus griseus
oxysterol binding protein activates Golgi/endosome-associated PI4K activity, required for PI4K activation by 25-hydroxycholesterol, overview Cricetulus griseus

Cloned(Commentary)

Cloned (Comment) Organism
isozymes PI4KIIalpha or PI4KIIIbeta Cricetulus griseus
transient expression of GFP-PI4KIIalpha in CHO cells, the tagged enzyme is present in perinuclear vesicles in control and 25-hydroxycholesterol-treated cells, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
cholesterol cholesterol sensitivity of PI4KIIalpha Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endosome
-
 Cricetulus griseus 5768
-
endosome
-
 Homo sapiens 5768
-
Golgi apparatus
-
 Cricetulus griseus 5794
-
Golgi apparatus
-
 Homo sapiens 5794
-
Golgi membrane
-
 Cricetulus griseus 139
-
Golgi membrane
-
 Homo sapiens 139
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Cricetulus griseus
Mg2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol Cricetulus griseus
-
 ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 ?
ATP + 1-phosphatidyl-1D-myo-inositol Homo sapiens
-
 ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Cricetulus griseus
-
-
-
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
CHO cell
-
 Cricetulus griseus
-
HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol
-
 Cricetulus griseus ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 ?
ATP + 1-phosphatidyl-1D-myo-inositol
-
 Homo sapiens ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
phosphatidylinositol 4-kinase IIalpha
-
 Cricetulus griseus
phosphatidylinositol 4-kinase IIalpha
-
 Homo sapiens
PI4K
-
 Cricetulus griseus
PI4K
-
 Homo sapiens
PI4KIIalpha
-
 Cricetulus griseus
PI4KIIalpha
-
 Homo sapiens
PtdIns 4-kinase
-
 Cricetulus griseus
PtdIns 4-kinase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Cricetulus griseus
ATP
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens inactivation of isozyme PI4KIIalpha by expression of siRNAs in HeLa cells additional information
Cricetulus griseus inactivation of isozymes PI4KIIalpha and PI4KIIabeta by expression of siRNAs in CHO cells and by RNAi additional information

General Information

General Information Comment Organism
physiological function phosphatidylinositol 4-kinase IIalpha is required for oxysterol binding protein-dependent activation of sphingomyelin synthesis in the Golgi apparatus, overview Cricetulus griseus
physiological function phosphatidylinositol 4-kinase IIalpha is required for oxysterol binding protein-dependent activation of sphingomyelin synthesis in the Golgi apparatus, overview Homo sapiens