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Literature summary for 2.7.1.67 extracted from

  • Zhao, X.; Varnai, P.; Tuymetova, G.; Balla, A.; Toth, Z.E.; Oker-Blom, C.; Roder, J.; Jeromin, A.; Balla, T.
    Interaction of neuronal calcium sensor-1 (NCS-1) with phosphatidylinositol 4-kinase b stimulates lipid kinase activity and affects membrane trafficking in COS-7 cells (2001), J. Biol. Chem., 276, 40183-40189.
    View publication on PubMed
Search for more literature for 2.7.1.67

Cloned(Commentary)

Cloned (Comment) Organism
-
 Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
adenosine
-
 Bos taurus
ATP
-
 Bos taurus
Wortmannin type II enzyme is inhibited by low concentrations, type III enzyme requires mM concentrations for inhibition Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
chromaffin granule
-
 Bos taurus 42583
-
membrane
-
 Rattus norvegicus 16020
-
membrane type II enzyme is almost exclusively found in membrane fraction Bos taurus 16020
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
54305
-
 x * 54305, calculation from nucleotide sequence Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol Rattus norvegicus
-
 ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 ?
ATP + 1-phosphatidyl-1D-myo-inositol Bos taurus phosphorylation of phosphatidylinositol at the D-4 position is an essential step in the biosynthesis of phosphatidylinositolpolyphosphates ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland PI4KII and PI4KIII Bos taurus
-
brain
-
 Rattus norvegicus
-
brain
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol
-
 Rattus norvegicus ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 ?
ATP + 1-phosphatidyl-1D-myo-inositol
-
 Bos taurus ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 ?
ATP + 1-phosphatidyl-1D-myo-inositol phosphorylation of phosphatidylinositol at the D-4 position is an essential step in the biosynthesis of phosphatidylinositolpolyphosphates Bos taurus ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 ?

Subunits

Subunits Comment Organism
?
-
 Rattus norvegicus
? x * 54305, calculation from nucleotide sequence Bos taurus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.045
-
 adenosine type II enzyme Bos taurus
0.088
-
 ATP type II enzyme Bos taurus