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Literature summary for 2.7.1.67 extracted from

  • Husebye, E.S.; Letcher, A.J.; Lander, D.J.; Flatmark, T.
    Purification and kinetic properties of a membrane-bound phosphatidylinositol kinase of the bovine adrenal medulla (1990), Biochim. Biophys. Acta, 1042, 330-337.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
poly(L-lysine) stimulates Bos taurus
Trifluoperazine stimulates activity of the purified enzyme less efficiently than that of the membrane-bound enzyme Bos taurus
Triton X-100 optimal activity at about 0.1% w/v Bos taurus
Triton X-100 maximal stimulation at 0.1% w/v Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
adenosine IC50: 0.07 mM Bos taurus
Ca2+
-
Bos taurus
MES IC50: 4 mM Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.017
-
phosphatidylinositol pH 7.0, 25°C Bos taurus
0.04
-
phosphatidylinositol
-
Bos taurus
0.055
-
ATP pH 7.0, 30°C Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
chromaffin granule
-
Bos taurus 42583
-
membrane integral membrane protein Bos taurus 16020
-
membrane bound to Bos taurus 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ stimulates Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
adrenal medulla
-
Bos taurus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0051
-
-
Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol
-
Bos taurus ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
broad, around Bos taurus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.07
-
IC50: 0.07 mM Bos taurus adenosine
4
-
IC50: 4 mM Bos taurus MES