Activating Compound | Comment | Organism | Structure |
---|---|---|---|
poly(L-lysine) | stimulates | Bos taurus | |
Trifluoperazine | stimulates activity of the purified enzyme less efficiently than that of the membrane-bound enzyme | Bos taurus | |
Triton X-100 | optimal activity at about 0.1% w/v | Bos taurus | |
Triton X-100 | maximal stimulation at 0.1% w/v | Bos taurus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
adenosine | IC50: 0.07 mM | Bos taurus | |
Ca2+ | - |
Bos taurus | |
MES | IC50: 4 mM | Bos taurus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.017 | - |
phosphatidylinositol | pH 7.0, 25°C | Bos taurus | |
0.04 | - |
phosphatidylinositol | - |
Bos taurus | |
0.055 | - |
ATP | pH 7.0, 30°C | Bos taurus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
chromaffin granule | - |
Bos taurus | 42583 | - |
membrane | integral membrane protein | Bos taurus | 16020 | - |
membrane | bound to | Bos taurus | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | stimulates | Bos taurus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Bos taurus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adrenal medulla | - |
Bos taurus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.0051 | - |
- |
Bos taurus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-phosphatidyl-1D-myo-inositol | - |
Bos taurus | ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
broad, around | Bos taurus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.07 | - |
IC50: 0.07 mM | Bos taurus | adenosine | |
4 | - |
IC50: 4 mM | Bos taurus | MES |