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Literature summary for 2.7.1.67 extracted from
- Purification and characterization of phosphatidylinositol 4-kinase from human erythrocyte membranes (1991), Eur. J. Biochem., 200, 179-185.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| adenosine | - |
Homo sapiens |  |
| Ca2+ | inhibition depends in Ca2+ concentration | Homo sapiens | |
| Co2+ | - |
Homo sapiens | |
| Fe2+ | - |
Homo sapiens | |
| Ni2+ | - |
Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.1 | - |
ATP | pH 7.2, 37°C | Homo sapiens | |
| 0.2 | - |
phosphatidylinositol | pH 7.2, 37°C | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Homo sapiens | 16020 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | optimal activation at 10 mM | Homo sapiens | |
| Mn2+ | optimal activation at 0.5 mM | Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 45000 | - |
x * 45000, SDS-PAGE | Homo sapiens |
| 50000 | - |
x * 50000, SDS-PAGE | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| erythrocyte | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 1.18 | - |
- |
Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 1-phosphatidyl-1D-myo-inositol | - |
Homo sapiens | ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 50000, SDS-PAGE | Homo sapiens |
| ? | x * 45000, SDS-PAGE | Homo sapiens |
| More | two enzyme species a 45000 Da enzyme and a 50000 Da enzyme | Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0019 | - |
Ca2+ | pH 7.2, 37°C, 45000 Da enzyme | Homo sapiens | |
| 0.0025 | - |
Ca2+ | pH 7.2, 37°C, 50000 Da enzyme | Homo sapiens | |
| 0.08 | - |
adenosine | pH 7.2, 37°C, 45000 Da enzyme | Homo sapiens | |
| 0.1 | - |
adenosine | pH 7.2, 37°C, 50000 Da enzyme | Homo sapiens | |
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Release 2023.1 (January 2023)
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