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Literature summary for 2.7.1.67 extracted from
- Phosphatidylinositol kinase of bovine adrenal chromaffin granules: kinetic properties and inhibition by low concentrations of Ca2+ (1988), Biochim. Biophys. Acta, 968, 261-265.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | reversibly inhibited by free Ca2+ in the nanomolar and low micromolar range, dependening on the concentration of Mg2+ | Bos taurus |  |
| KCl | slight inhibition | Bos taurus | |
| NaCl | slight inhibition | Bos taurus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.044 | - |
ATP | in presence of 1 mM MgCl2 | Bos taurus | |
| 0.044 | - |
ATP | ATP in form of MgATP2- | Bos taurus | |
| 0.062 | - |
ATP | in presence of 20 mM MgCl2 | Bos taurus | |
| 0.062 | - |
ATP | ATP in form of MgATP2- | Bos taurus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| chromaffin granule | - |
Bos taurus | 42583 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | highly dependent on Mg2+, maximal stimulation at 60 mM | Bos taurus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adrenal gland | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 1-phosphatidyl-1D-myo-inositol | - |
Bos taurus | ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
? | |
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