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Literature summary for 2.7.1.67 extracted from

  • Vogel, S.; Hoppe, J.
    Polyamines stimulate the phosphorylation of phosphatidylinositol in membranes from A431 cells (1986), Eur. J. Biochem., 154, 253-257.
    View publication on PubMed
Search for more literature for 2.7.1.67

Activating Compound

Activating Compound Comment Organism Structure
histone stimulates Homo sapiens
phosvitin stimulates Homo sapiens
poly(L-lysine) stimulates Homo sapiens
Polyarginine stimulates Homo sapiens
spermidine half-maximal stimulation at 1.5 mM Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2'-dATP
-
 Homo sapiens
3'-dATP
-
 Homo sapiens
8-bromo-ATP
-
 Homo sapiens
adenosine
-
 Homo sapiens
ADP
-
 Homo sapiens
AMP
-
 Homo sapiens
cAMP
-
 Homo sapiens
GTP
-
 Homo sapiens
N6-dimethylamine-adenosine 5'-triphosphate
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.02
-
 ATP pH 7.4, 25°C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Homo sapiens 16020
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-431 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol
-
 Homo sapiens ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.01
-
 ADP pH 7.4, 25°C, in absence of spermidine Homo sapiens
0.012
-
 3'-dATP pH 7.4, 25°C, in absence of spermidine Homo sapiens
0.013
-
 GTP pH 7.4, 25°C, in absence of spermidine Homo sapiens
0.014
-
 2'-dATP pH 7.4, 25°C, in presence of 3 mM spermidine Homo sapiens
0.04
-
 N6-dimethylamine-adenosine 5'-triphosphate pH 7.4, 25°C, in presence of 3 mM spermidine Homo sapiens
0.07
-
 adenosine pH 7.4, 25°C, in absence of spermidine Homo sapiens
0.11
-
 8-bromo-ATP pH 7.4, 25°C, in presence of 3 mM spermidine Homo sapiens
0.5
-
 cAMP pH 7.4, 25°C, in absence of spermidine Homo sapiens
0.53
-
 AMP pH 7.4, 25°C, in absence of spermidine Homo sapiens
1.9
-
 N6-dimethylamine-adenosine 5'-triphosphate pH 7.4, 25°C, in absence of spermidine Homo sapiens