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Literature summary for 2.7.1.66 extracted from

  • Huang, L.Y.; Wang, S.C.; Cheng, T.R.; Wong, C.H.
    Undecaprenyl Phosphate Phosphatase Activity of Undecaprenol Kinase Regulates the Lipid Pool in Gram-Positive Bacteria (2017), Biochemistry, 56, 5417-5427 .
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
A109S the mutant shows about 85% of wild type activity Streptococcus mutans
D106A the activity of the mutant is less than 5% of the activity of wild type enzyme Streptococcus mutans
D7A the mutant shows about 70% of wild type activity Streptococcus mutans
D90A the activity of the mutant is less than 10% of the activity of wild type enzyme Streptococcus mutans
D94A the mutant shows about 65% of wild type activity Streptococcus mutans
E38A the mutant shows about 35% of wild type activity Streptococcus mutans
E79A the mutant shows about 1% of wild type activity Streptococcus mutans
E86A the mutant shows about 1% of wild type activity Streptococcus mutans
H44A the mutant shows about 58% of wild type activity Streptococcus mutans
H44E the mutant shows about 1% of wild type activity Streptococcus mutans
H96A the mutant shows wild type activity Streptococcus mutans
K102A the mutant shows about 80% of wild type activity Streptococcus mutans
K105A the mutant shows about 20% of wild type activity Streptococcus mutans
N40A the mutant shows about 75% of wild type activity Streptococcus mutans
N82A the mutant shows about 1% of wild type activity Streptococcus mutans
N87A the mutant shows about 85% of wild type activity Streptococcus mutans
R39A the mutant shows about 85% of wild type activity Streptococcus mutans
S11A the mutant shows about 95% of wild type activity Streptococcus mutans
S22A the mutant shows about 105% of wild type activity Streptococcus mutans
S23A the mutant shows wild type activity Streptococcus mutans
S83A the mutant shows about 105% of wild type activity Streptococcus mutans
T19A the mutant shows about 95% of wild type activity Streptococcus mutans
T21A the mutant shows about 95% of wild type activity Streptococcus mutans
T29A the mutant shows about 110% of wild type activity Streptococcus mutans

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.118
-
undecaprenol at pH 8.0 and 37°C Streptococcus mutans
0.218
-
ATP at pH 8.0 and 37°C Streptococcus mutans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + undecaprenol Streptococcus mutans
-
ADP + undecaprenyl phosphate
-
?

Organism

Organism UniProt Comment Textmining
Streptococcus mutans
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + undecaprenol
-
Streptococcus mutans ADP + undecaprenyl phosphate
-
?
additional information the enzyme is also a Mg-ADP-dependent undecaprenyl phosphate phosphatase catalyzing the hydrolysis of C55P to C55OH and a free inorganic phosphate Streptococcus mutans ?
-
-

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.4
-
ATP at pH 8.0 and 37°C Streptococcus mutans
4
-
undecaprenol at pH 8.0 and 37°C Streptococcus mutans