Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.1.60 extracted from

  • Hinderlich, S.; Neuenschwander, M.; Wratil, P.R.; Oder, A.; Lisurek, M.; Nguyen, L.D.; von Kries, J.P.; Hackenberger, C.P.R.
    Small molecules targeting human N-acetylmannosamine kinase (2017), ChemBioChem, 18, 1279-1285 .
    View publication on PubMed
Search for more literature for 2.7.1.60

Activating Compound

Activating Compound Comment Organism Structure
bovine serum albumin
-
 Homo sapiens
dithiothreitol
-
 Homo sapiens
EGTA
-
 Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
the His-tagged enzyme is expressed in Escherichia coli Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(2Z)-1-(4-chlorophenyl)-3-(2-hydroxy-5-nitrophenyl)-2-(1H-1,2,4-triazol-1-yl)prop-2-en-1-one FMP-209613 Homo sapiens
(2Z)-3-(4-fluorophenyl)-1-(4-methylphenyl)-2-(1H-1,2,4-triazol-1-yl)prop-2-en-1-one FMP-209617 Homo sapiens
2,3-bis[(2-hydroxyethyl)sulfanyl]naphthalene-1,4-dione FMP-404919 Homo sapiens
2-[(2,4-dinitrophenyl)sulfanyl]-1,3-benzoxazole FMP-402581 Homo sapiens
5-(anthracen-9-ylmethylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione FMP-402534 Homo sapiens
6-6'-diselenobis-(2-acetamido-2-deoxy-D-mannopyranose)
-
 Homo sapiens
7-nitro-10-(3-nitrophenyl)pyrimido[4,5-b]quinoline-2,4(3H,10H)-dione FMP-200208 Homo sapiens
N-[4-[(E)-(3,5-dioxo-1-phenylpyrazolidin-4-ylidene)methyl]phenyl]acetamide FMP-100705 Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ highest activity at 1.6 mM Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + N-acyl-D-mannosamine Homo sapiens
-
 ADP + N-acyl-D-mannosamine 6-phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + N-acyl-D-mannosamine
-
 Homo sapiens ADP + N-acyl-D-mannosamine 6-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
MNK
-
 Homo sapiens
N-acetylmannosamine kinase
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0004
-
 at pH 8.0 and 37°C Homo sapiens N-[4-[(E)-(3,5-dioxo-1-phenylpyrazolidin-4-ylidene)methyl]phenyl]acetamide
0.0006
-
 at pH 8.0 and 37°C Homo sapiens 5-(anthracen-9-ylmethylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
0.0072
-
 at pH 8.0 and 37°C Homo sapiens 2,3-bis[(2-hydroxyethyl)sulfanyl]naphthalene-1,4-dione
0.011
-
 at pH 8.0 and 37°C Homo sapiens (2Z)-1-(4-chlorophenyl)-3-(2-hydroxy-5-nitrophenyl)-2-(1H-1,2,4-triazol-1-yl)prop-2-en-1-one
0.8
-
 at pH 8.0 and 37°C Homo sapiens 6-6'-diselenobis-(2-acetamido-2-deoxy-D-mannopyranose)