Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21-CodonPlus (DE3)-RIL cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,3-dimethyl-4-(trifluoromethyl)-1,7-dihydro-6H-pyrazolo[3,4-b]pyridin-6-one | - |
Homo sapiens | |
1,6-dimethyl-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile | - |
Homo sapiens | |
2-ethyl-4-(trifluoromethyl)-2,7-dihydro-6H-pyrazolo[3,4-b]pyridin-6-one | - |
Homo sapiens | |
2-hydroxy-6-propyl-4-(trifluoromethyl)pyridine-3-carbonitrile | - |
Homo sapiens | |
2-methoxy-4-(trifluoromethyl)pyridine-3-carboxylic acid | - |
Homo sapiens | |
3-acetyl-5-chloropyridine-2-carboxylic acid | - |
Homo sapiens | |
4-(trifluoromethyl)picolinic acid | - |
Homo sapiens | |
4-(trifluoromethyl)pyridine-2-carboxylic acid | also named 4-(trifluoromethyl)picolinic acid | Homo sapiens | |
4-oxo-1,4-dihydropyridine-2,6-dicarboxylic acid | - |
Homo sapiens | |
5-(cyanomethyl)pyridine-2-carboxylic acid | - |
Homo sapiens | |
5-carbamoyl-3-chloropyridine-2-carboxylic acid | - |
Homo sapiens | |
6-(cyclopentylcarbamoyl)pyridine-2-carboxylic acid | - |
Homo sapiens | |
6-(pyrrolidin-1-ylcarbonyl)pyridine-2-carboxylic acid | - |
Homo sapiens | |
6-acetylpicolinic acid | - |
Homo sapiens | |
6-acetylpyridine-2-carboxylic acid | also named 6-acetylpicolinic acid | Homo sapiens | |
6-carbamoylpyridine-2-carboxylic acid | - |
Homo sapiens | |
6-cyclopropyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-3-amine | - |
Homo sapiens | |
6-methyl-4-(trifluoromethyl)pyridin-2(1H)-one | - |
Homo sapiens | |
methyl 5,6-diaminopyridine-2-carboxylate | - |
Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | 65 mM used in assay conditions | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + N-acyl-D-mannosamine | Homo sapiens | - |
ADP + N-acyl-D-mannosamine 6-phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
Ni-NTA column chromatography | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + N-acyl-D-mannosamine | - |
Homo sapiens | ADP + N-acyl-D-mannosamine 6-phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MNK | - |
Homo sapiens |
N-acetylmannosamine kinase | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.076 | - |
at pH 8.0 and 37°C | Homo sapiens | 6-carbamoylpyridine-2-carboxylic acid | |
0.078 | - |
at pH 8.0 and 37°C | Homo sapiens | 4-oxo-1,4-dihydropyridine-2,6-dicarboxylic acid | |
0.08 | - |
at pH 8.0 and 37°C | Homo sapiens | 6-(pyrrolidin-1-ylcarbonyl)pyridine-2-carboxylic acid | |
0.4 | - |
at pH 8.0 and 37°C | Homo sapiens | 1,6-dimethyl-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile | |
0.7 | - |
at pH 8.0 and 37°C | Homo sapiens | 3-acetyl-5-chloropyridine-2-carboxylic acid | |
0.7 | - |
at pH 8.0 and 37°C | Homo sapiens | 6-acetylpyridine-2-carboxylic acid | |
0.7 | - |
at pH 8.0 and 37°C | Homo sapiens | 6-acetylpicolinic acid | |
0.8 | - |
at pH 8.0 and 37°C | Homo sapiens | 5-carbamoyl-3-chloropyridine-2-carboxylic acid | |
0.8 | - |
at pH 8.0 and 37°C | Homo sapiens | methyl 5,6-diaminopyridine-2-carboxylate | |
0.9 | - |
at pH 8.0 and 37°C | Homo sapiens | 2-methoxy-4-(trifluoromethyl)pyridine-3-carboxylic acid | |
0.9 | - |
at pH 8.0 and 37°C | Homo sapiens | 4-(trifluoromethyl)pyridine-2-carboxylic acid | |
0.9 | - |
at pH 8.0 and 37°C | Homo sapiens | 4-(trifluoromethyl)picolinic acid | |
1.6 | - |
at pH 8.0 and 37°C | Homo sapiens | 6-methyl-4-(trifluoromethyl)pyridin-2(1H)-one | |
2.5 | - |
IC50 above 2.5 mM, at pH 8.0 and 37°C | Homo sapiens | 1,3-dimethyl-4-(trifluoromethyl)-1,7-dihydro-6H-pyrazolo[3,4-b]pyridin-6-one | |
2.5 | - |
IC50 above 2.5 mM, at pH 8.0 and 37°C | Homo sapiens | 2-ethyl-4-(trifluoromethyl)-2,7-dihydro-6H-pyrazolo[3,4-b]pyridin-6-one | |
2.5 | - |
IC50 above 2.5 mM, at pH 8.0 and 37°C | Homo sapiens | 2-hydroxy-6-propyl-4-(trifluoromethyl)pyridine-3-carbonitrile | |
2.5 | - |
IC50 above 2.5 mM, at pH 8.0 and 37°C | Homo sapiens | 5-(cyanomethyl)pyridine-2-carboxylic acid | |
2.5 | - |
IC50 above 2.5 mM, at pH 8.0 and 37°C | Homo sapiens | 6-cyclopropyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-3-amine | |
3.7 | - |
at pH 8.0 and 37°C | Homo sapiens | 6-(cyclopentylcarbamoyl)pyridine-2-carboxylic acid |