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Literature summary for 2.7.1.60 extracted from

  • Tong, Y.; Tempel, W.; Nedyalkova, L.; Mackenzie, F.; Park, H.W.
    Crystal structure of the N-acetylmannosamine kinase domain of GNE (2009), PLoS ONE, 4, e7165.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
His-tag, kinase domain expressed in Escherichia coli BL21(D3) CodonPlus-RIL Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
kinase domain Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9Y223
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Subunits

Subunits Comment Organism
homodimer kinase domain: in solution, with small populations of monomer and higher-order oligomer in equilibrium with the dimer, gel filtration Homo sapiens
homohexamer kinase domain, crystal structure Homo sapiens

Synonyms

Synonyms Comment Organism
N-acetylmannosamine kinase bifunctional enzyme: UDP-N-acetylglucosamine 2-epimerase /N-acetylmannosamine kinase Homo sapiens

General Information

General Information Comment Organism
malfunction mutations cause sialurea or inclusion body myopathy/Nonaka myopathy Homo sapiens
metabolism sialic acid biosynthesis pathway Homo sapiens