Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ADP | strong competitive inhibitor | Escherichia coli | |
D-glucosamine | - |
Escherichia coli | |
N-Methyl-D-glucosamine | - |
Escherichia coli |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00005 | - |
N-acetyl-D-glucosamine | 37°C, pH 7.8 | Escherichia coli | |
0.00014 | - |
ATP | 37°C, pH 7.8 | Escherichia coli | |
0.00025 | - |
ITP | 37°C, pH 7.8 | Escherichia coli | |
0.005 | - |
D-glucose | 37°C, pH 7.8 | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + N-acetyl-D-glucosamine | Escherichia coli | - |
ADP + N-acetyl-D-glucosamine 6-phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Escherichia coli |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
4.6 | - |
purified enzyme, 37°C, pH 7.8 | Escherichia coli |
Storage Stability | Organism |
---|---|
-20°C, stable for several months | Escherichia coli |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + D-glucose | 15% of the rate with N-acetyl-D-glucosamine | Escherichia coli | ADP + D-glucose 6-phosphate | - |
? | |
ATP + N-acetyl-D-glucosamine | - |
Escherichia coli | ADP + N-acetyl-D-glucosamine 6-phosphate | - |
? | |
ITP + N-acetyl-D-glucosamine | 75% of the activity with ATP | Escherichia coli | IDP + N-acetyl-D-glucosamine 6-phosphate | - |
? | |
additional information | N-methyl-D-glucosamine, D-glucosamine, N-acetyl-D-galactosamine, N-acetyl-D-mannosamine do not serve as substrates, very low activities with UTP, GTP and CTP | Escherichia coli | ? | - |
? |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
65 | - |
heat treatment for 5 min included in purification procedure | Escherichia coli |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | 9.5 | - |
Escherichia coli |
pH Stability | pH Stability Maximum | Comment | Organism |
---|---|---|---|
9.5 | - |
no loss of activity within 30 min at 30°C | Escherichia coli |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.001 | - |
N-Methyl-D-glucosamine | 37°C, pH 7.8 | Escherichia coli | |
0.01 | - |
D-glucosamine | 37°C, pH 7.8 | Escherichia coli |