Cloned (Comment) | Organism |
---|---|
functional expression of HA-tagged FKP in Saccharomyces cerevisiae strain W303-1A, the biosynthesis of GDP-D-Ara in the recombinant Saccharomyces cerevisiae strain harboring the FKP gene can occur through a mechanism akin to that of GDP-L-Fuc via the salvage pathway. Expression of a loss-of-function FKP mutant in yeast | Bacteroides fragilis |
General Stability | Organism |
---|---|
instability of the enzyme occurs through chemical reduction in disulfide bonds of FKP protein, resulting in degradation | Bacteroides fragilis |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Bacteroides fragilis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-fucose | Bacteroides fragilis | - |
ADP + beta-L-fucose 1-phosphate | - |
? | |
ATP + L-fucose | Bacteroides fragilis 9343 | - |
ADP + beta-L-fucose 1-phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bacteroides fragilis | - |
- |
- |
Bacteroides fragilis 9343 | - |
- |
- |
no activity in Saccharomyces cerevisiae | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-fucose | - |
Bacteroides fragilis | ADP + beta-L-fucose 1-phosphate | - |
? | |
ATP + L-fucose | - |
Bacteroides fragilis 9343 | ADP + beta-L-fucose 1-phosphate | - |
? | |
additional information | fucokinase:GDP-fucose pyrophosphorylase is a dual activity enzyme metabolizing fucose and nucleotide-sugar | Bacteroides fragilis | ? | - |
? | |
additional information | fucokinase:GDP-fucose pyrophosphorylase is a dual activity enzyme metabolizing fucose and nucleotide-sugar | Bacteroides fragilis 9343 | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
FKP | - |
Bacteroides fragilis |
Fuk | - |
Bacteroides fragilis |
L-fucokinase/guanosine 5'-diphosphate-L-fucose pyrophosphorylase | - |
Bacteroides fragilis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Bacteroides fragilis |
General Information | Comment | Organism |
---|---|---|
metabolism | the enzyme catalyzes the first step of the salvage pathway converting exogenous L-Fuc to GDP-L-Fuc | Bacteroides fragilis |
physiological function | the bifunctional L-Fuc pyrophosphorylase, FKP, converts L-Fuc into GDP-L-Fuc via an L-Fuc-1-phosphate intermediate | Bacteroides fragilis |