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Literature summary for 2.7.1.48 extracted from
- Human uridine-cytidine kinase phosphorylation of ribavirin: a convenient method for activation of ribavirin for conjugation to proteins (2008), J. Biomed. Sci., 15, 205-213.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | liver-specific targeting of ribavirin by conjugation with asialoglycoprotein to enhance its antiviral activity. Conjugation reaction starts with ribavirin phosphorylation by uridine kinase followed by direct conjugation to asioloosomucoid | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
isoform Uvk1 | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + cytidine | 89% of substrate phosphorylated, within 2 h incubation | Homo sapiens | ADP + CMP | - |
? |  |
| ATP + ribavirin | 13% of substrate phosphorylated, within 2 h incubation | Homo sapiens | ADP + ribavirin monophosphate | - |
? | |
| ATP + uridine | 56% of substrate phosphorylated, within 2 h incubation | Homo sapiens | ADP + UMP | - |
? | |
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Release 2023.1 (January 2023)
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