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Literature summary for 2.7.1.48 extracted from

  • Appleby, T.C.; Larson, G.; Cheney, I.W.; Walker, H.; Wu, J.Z.; Zhong, W.; Hong, Z.; Yao, N.
    Structure of human uridine-cytidine kinase 2 determined by SIRAS using a rotating-anode X-ray generator and a single samarium derivative (2005), Acta Crystallogr. Sect. D, 61, 278-284.
    View publication on PubMed
Search for more literature for 2.7.1.48

Application

Application Comment Organism
medicine target for antitumor and antiviral drug design Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed with a glutathione-S-transferase tag Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
in complex with Mg2+, ADP, and CMP by sitting drop vapor diffusion method Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
CTP feedback inhibition Homo sapiens
UTP feedback inhibition Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ bound to enzyme, can be replaced by Sm2+ Homo sapiens
samarium four binding sites two of which are located in the active sites Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + cytidine Homo sapiens rate limiting enzyme of the pyrimidine-nucleotide salvage pathway ADP + CMP
-
 ?
ATP + uridine Homo sapiens rate limiting enzyme of the pyrimidine-nucleotide salvage pathway ADP + UMP
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9BZX2
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant enzyme using glutathione-S-transferase tag Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + cytidine
-
 Homo sapiens ADP + CMP
-
 ?
ATP + cytidine rate limiting enzyme of the pyrimidine-nucleotide salvage pathway Homo sapiens ADP + CMP
-
 ?
ATP + uridine
-
 Homo sapiens ADP + UMP
-
 ?
ATP + uridine rate limiting enzyme of the pyrimidine-nucleotide salvage pathway Homo sapiens ADP + UMP
-
 ?

Subunits

Subunits Comment Organism
tetramer two asymmetric dimers form a tetramer, crystal structure analysis Homo sapiens

Synonyms

Synonyms Comment Organism
uridine-cytidine kinase 2
-
 Homo sapiens