BRENDA - Enzyme Database show
show all sequences of 2.7.1.48

Uridine kinase from Ehrlich ascites carcinoma. Purification and properties of homogeneous enzyme

Payne, R.C.; Cheng, N.; Traut, T.W.; J. Biol. Chem. 260, 10242-10247 (1985)

Data extracted from this reference:

General Stability
General Stability
Organism
pure enzyme is very sensitive to freezing
Mus musculus
Inhibitors
Inhibitors
Commentary
Organism
Structure
CTP
-
Mus musculus
UTP
-
Mus musculus
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.04
-
uridine
pH 8.0, 22°C
Mus musculus
0.057
-
cytidine
pH 8.0, 22°C
Mus musculus
0.069
-
5-fluorouridine
pH 8.0, 22°C
Mus musculus
0.2
-
3-deazauridine
pH 8.0, 22°C
Mus musculus
0.34
-
6-azauridine
pH 8.0, 22°C
Mus musculus
0.45
-
ATP
pH 8.0, 22°C
Mus musculus
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
31000
-
x * 31000, enzyme exists in multiple interconvertible oligomeric forms, SDS-PAGE
Mus musculus
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + uridine
Mus musculus
rate limiting enzyme of pyrimidine salvage pathway
ADP + UMP
-
Mus musculus
?
ATP + uridine
Mus musculus
rate-limiting enzyme in anabolism of uridine and cytidine
ADP + UMP
-
Mus musculus
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Mus musculus
-
-
-
Purification (Commentary)
Commentary
Organism
DE-52, ammonium sulfate, ATP-agarose column
Mus musculus
Reaction
Reaction
Commentary
Organism
ATP + uridine = ADP + UMP
sequential mechanism
Mus musculus
Source Tissue
Source Tissue
Commentary
Organism
Textmining
Ehrlich ascites carcinoma cell
-
Mus musculus
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
283
-
-
Mus musculus
Storage Stability
Storage Stability
Organism
-20°C, 50% glycerol, several months, no loss of activity
Mus musculus
0°C, 8 weeks, 20% loss of activity
Mus musculus
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + 3-deazauridine
-
641647
Mus musculus
ADP + 3-deazauridine 5'-monophosphate
-
641647
Mus musculus
?
ATP + 5-fluorouridine
-
641647
Mus musculus
ADP + 5-fluorouridine 5'-monophosphate
-
641647
Mus musculus
?
ATP + 6-azauridine
-
641647
Mus musculus
ADP + 6-azauridine 5'-monophosphate
-
641647
Mus musculus
?
ATP + cytidine
-
641647
Mus musculus
ADP + CMP
-
-
-
-
ATP + uridine
-
641647
Mus musculus
ADP + UMP
-
641647
Mus musculus
?
ATP + uridine
rate limiting enzyme of pyrimidine salvage pathway
641647
Mus musculus
ADP + UMP
-
641647
Mus musculus
?
ATP + uridine
rate-limiting enzyme in anabolism of uridine and cytidine
641647
Mus musculus
ADP + UMP
-
641647
Mus musculus
?
Subunits
Subunits
Commentary
Organism
?
x * 31000, enzyme exists in multiple interconvertible oligomeric forms, SDS-PAGE
Mus musculus
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
22
-
assay at
Mus musculus
37
-
assay at
Mus musculus
General Stability (protein specific)
General Stability
Organism
pure enzyme is very sensitive to freezing
Mus musculus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
CTP
-
Mus musculus
UTP
-
Mus musculus
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.04
-
uridine
pH 8.0, 22°C
Mus musculus
0.057
-
cytidine
pH 8.0, 22°C
Mus musculus
0.069
-
5-fluorouridine
pH 8.0, 22°C
Mus musculus
0.2
-
3-deazauridine
pH 8.0, 22°C
Mus musculus
0.34
-
6-azauridine
pH 8.0, 22°C
Mus musculus
0.45
-
ATP
pH 8.0, 22°C
Mus musculus
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
31000
-
x * 31000, enzyme exists in multiple interconvertible oligomeric forms, SDS-PAGE
Mus musculus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + uridine
Mus musculus
rate limiting enzyme of pyrimidine salvage pathway
ADP + UMP
-
Mus musculus
?
ATP + uridine
Mus musculus
rate-limiting enzyme in anabolism of uridine and cytidine
ADP + UMP
-
Mus musculus
?
Purification (Commentary) (protein specific)
Commentary
Organism
DE-52, ammonium sulfate, ATP-agarose column
Mus musculus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
Ehrlich ascites carcinoma cell
-
Mus musculus
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
283
-
-
Mus musculus
Storage Stability (protein specific)
Storage Stability
Organism
-20°C, 50% glycerol, several months, no loss of activity
Mus musculus
0°C, 8 weeks, 20% loss of activity
Mus musculus
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + 3-deazauridine
-
641647
Mus musculus
ADP + 3-deazauridine 5'-monophosphate
-
641647
Mus musculus
?
ATP + 5-fluorouridine
-
641647
Mus musculus
ADP + 5-fluorouridine 5'-monophosphate
-
641647
Mus musculus
?
ATP + 6-azauridine
-
641647
Mus musculus
ADP + 6-azauridine 5'-monophosphate
-
641647
Mus musculus
?
ATP + cytidine
-
641647
Mus musculus
ADP + CMP
-
-
-
-
ATP + uridine
-
641647
Mus musculus
ADP + UMP
-
641647
Mus musculus
?
ATP + uridine
rate limiting enzyme of pyrimidine salvage pathway
641647
Mus musculus
ADP + UMP
-
641647
Mus musculus
?
ATP + uridine
rate-limiting enzyme in anabolism of uridine and cytidine
641647
Mus musculus
ADP + UMP
-
641647
Mus musculus
?
Subunits (protein specific)
Subunits
Commentary
Organism
?
x * 31000, enzyme exists in multiple interconvertible oligomeric forms, SDS-PAGE
Mus musculus
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
22
-
assay at
Mus musculus
37
-
assay at
Mus musculus
Other publictions for EC 2.7.1.48
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
737778
van Kuilenburg
The pivotal role of uridine-cy ...
Homo sapiens
Biochim. Biophys. Acta
1862
1504-1512
2016
-
-
1
-
-
-
-
-
2
-
-
2
-
2
-
-
1
-
-
10
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
-
2
-
-
-
2
-
20
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
739129
Malami
In silico discovery of potenti ...
Homo sapiens
Molecules
21
417
2016
-
-
-
-
-
-
4
-
-
-
-
1
-
2
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
3
4
-
-
-
-
-
1
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
739594
Tomoike
Structural and biochemical stu ...
Thermus thermophilus, Thermus thermophilus HB8 / ATCC 27634 / DSM 579
Protein J.
34
411-420
2015
-
-
1
1
-
-
-
-
-
-
-
2
-
4
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
2
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
738736
Qian
Phosphorylation of uridine and ...
Escherichia coli, Lactobacillus delbrueckii subsp. bulgaricus, Lactobacillus delbrueckii subsp. bulgaricus ATCC 11842
J. Biotechnol.
188
81-87
2014
-
-
2
-
-
-
-
-
-
2
4
6
-
7
-
-
-
-
-
-
-
-
31
2
2
-
-
-
4
-
-
8
-
-
-
-
-
2
8
-
-
-
-
-
-
-
-
2
4
6
-
-
-
-
-
-
-
-
31
2
2
-
-
-
4
-
-
-
-
-
-
-
-
-
721643
Tomoike
A single amino acid limits the ...
Thermus thermophilus, Thermus thermophilus HB8 / ATCC 27634 / DSM 579
Biochemistry
50
4597-4607
2011
-
-
1
1
1
-
2
9
-
3
-
8
-
95
-
-
1
-
-
-
-
-
8
-
1
-
1
8
1
-
-
1
3
-
-
-
-
1
2
1
1
-
-
2
3
9
-
6
-
8
-
-
-
1
-
-
-
-
8
-
2
-
1
8
2
-
-
-
-
2
3
-
7
7
706039
Smith
Quantum mechanics/molecular me ...
Homo sapiens
Org. Biomol. Chem.
7
2716-2724
2009
-
-
-
-
-
-
-
1
-
1
-
-
-
2
-
-
-
-
-
1
-
-
2
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
1
-
-
-
-
-
-
-
-
1
1
706070
Lossani
Thymidine kinase and uridine-c ...
Entamoeba histolytica
Parasitology
136
595-602
2009
-
-
1
-
-
-
4
2
-
1
1
-
-
2
-
-
1
-
-
-
1
-
2
1
-
-
-
-
1
-
-
-
-
-
3
-
-
1
-
-
-
-
3
4
-
2
-
1
1
-
-
-
-
1
-
-
1
-
2
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
693270
Jukic
Human uridine-cytidine kinase ...
Homo sapiens
J. Biomed. Sci.
15
205-213
2008
-
1
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
694223
Qimron
Inadequate inhibition of host ...
Escherichia coli
Mol. Microbiol.
67
448-457
2008
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
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1
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-
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1
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-
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-
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-
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
676161
Balestri
Key role of uridine kinase and ...
Rattus norvegicus
Neurochem. Int.
51
517-523
2007
-
-
-
-
-
-
-
-
-
-
-
1
-
3
-
-
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-
-
1
-
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2
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1
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1
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-
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1
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-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
676556
Islam
Functional characterization of ...
Arabidopsis thaliana
Plant Mol. Biol.
63
465-477
2007
-
-
1
-
1
-
-
-
-
-
1
-
-
4
-
-
-
-
-
4
-
-
2
2
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
1
-
-
-
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1
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-
-
4
-
-
2
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
676246
Niemeyer
Evaluation of uridine metaboli ...
Homo sapiens
Nucleosides Nucleotides Nucleic Acids
25
1215-1219
2006
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
660609
Appleby
Structure of human uridine-cyt ...
Homo sapiens
Acta Crystallogr. Sect. D
61
278-284
2005
-
1
1
1
-
-
2
-
-
2
-
2
-
2
-
-
1
-
-
-
-
-
4
1
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
1
-
-
-
2
-
-
-
2
-
2
-
-
-
1
-
-
-
-
4
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
663248
Vidair
Mg2+ as activator of uridine p ...
Mus musculus
Proc. Natl. Acad. Sci. USA
102
662-666
2005
-
-
-
-
-
-
3
-
-
1
-
2
-
2
-
-
-
-
-
1
-
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4
-
-
-
-
-
-
-
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-
-
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3
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1
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2
-
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1
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
673504
Glavas-Obrovac
Metabolic effects of novel N-1 ...
Homo sapiens
Farmaco
60
479-483
2005
1
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
1
-
-
-
-
-
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-
-
1
-
-
-
1
-
-
1
-
-
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1
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-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
661576
Murata
A crucial role of uridine/cyti ...
Homo sapiens
Drug Metab. Dispos.
32
1178-1182
2004
-
-
1
-
1
-
-
-
-
-
2
4
-
1
-
-
1
-
-
2
-
-
8
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
2
4
-
-
-
1
-
2
-
-
8
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
663411
Suzuki
Structural basis for the speci ...
Homo sapiens
Structure
12
751-764
2004
-
1
-
1
-
-
2
-
-
1
2
2
-
2
-
-
-
-
-
-
-
-
6
1
-
-
-
-
-
-
-
-
-
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-
-
1
-
-
1
-
-
-
2
-
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-
1
2
2
-
-
-
-
-
-
-
-
6
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
641656
Suzuki
Crystallization and preliminar ...
Homo sapiens
Acta Crystallogr. Sect. D
59
1477-1478
2003
-
-
-
1
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-
-
-
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2
-
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1
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16
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15
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641655
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Phosphorylation of uridine and ...
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2
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641653
Shen
Increased uridine kinase (ATP: ...
Homo sapiens, Rattus norvegicus
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1998
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6
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2
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1
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641647
Payne
Uridine kinase from Ehrlich as ...
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1985
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2
7
1
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641640
Ahmed
Properties of uridine-cytidine ...
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1980
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3
3
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641643
Orengo
Uridine-cytidine kinase from N ...
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Methods Enzymol.
51
299-307
1978
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4
3
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4
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2
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3
18
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2
3
18
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3
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641644
Valentin-Hansen
Uridine-cytidine kinase from E ...
Escherichia coli
Methods Enzymol.
51
308-314
1978
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1
2
2
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1
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2
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9
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1
1
9
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1
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1
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641645
Anderson
Uridine-cytidine kinase from a ...
Mus musculus
Methods Enzymol.
51
314-321
1978
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1
4
4
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5
1
1
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1
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12
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1
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1
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12
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1
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641641
Drake
Characteristics of the enzyme ...
Homo sapiens
Biochem. Pharmacol.
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64-66
1977
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3
1
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3
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641648
Fulchignoni-Lataud
Uridine--cytidine kinase from ...
Rattus norvegicus
Eur. J. Biochem.
69
217-222
1976
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1
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2
1
1
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2
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641652
Cihak
Stability of the insoluble for ...
Bos taurus
Hoppe-Seyler's Z. Physiol. Chem.
357
345-350
1976
2
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2
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1
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641649
Liacouras
Uridine-cytidine kinase. Purif ...
Mus musculus
Arch. Biochem. Biophys.
168
66-73
1975
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2
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1
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13
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1
13
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1
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641650
Liacouras
Uridine-cytidine kinase. Kinet ...
Mus musculus
Arch. Biochem. Biophys.
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74-80
1975
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641651
Cihak
Pb-precipitated protein fracti ...
Bos taurus
FEBS Lett.
51
133-136
1975
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2
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641642
Krystal
The partial purification and p ...
Mus musculus
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1973
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1
1
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1
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641639
Orengo
Regulation of a thermostable p ...
Geobacillus stearothermophilus, Rattus norvegicus
Biochemistry
11
1761-1767
1972
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641646
Orengo
Regulation of enzymic activity ...
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1
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641638
Sköld
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Uridine kinase from ehrlich as ...
Mus musculus
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1
1
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4
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7
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1
1
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