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Literature summary for 2.7.1.48 extracted from

  • Payne, R.C.; Cheng, N.; Traut, T.W.
    Uridine kinase from Ehrlich ascites carcinoma. Purification and properties of homogeneous enzyme (1985), J. Biol. Chem., 260, 10242-10247.
    View publication on PubMed

General Stability

General Stability Organism
pure enzyme is very sensitive to freezing Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
CTP
-
Mus musculus
UTP
-
Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.04
-
uridine pH 8.0, 22°C Mus musculus
0.057
-
cytidine pH 8.0, 22°C Mus musculus
0.069
-
5-fluorouridine pH 8.0, 22°C Mus musculus
0.2
-
3-deazauridine pH 8.0, 22°C Mus musculus
0.34
-
6-azauridine pH 8.0, 22°C Mus musculus
0.45
-
ATP pH 8.0, 22°C Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
31000
-
x * 31000, enzyme exists in multiple interconvertible oligomeric forms, SDS-PAGE Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + uridine Mus musculus rate limiting enzyme of pyrimidine salvage pathway ADP + UMP
-
?
ATP + uridine Mus musculus rate-limiting enzyme in anabolism of uridine and cytidine ADP + UMP
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
DE-52, ammonium sulfate, ATP-agarose column Mus musculus

Reaction

Reaction Comment Organism Reaction ID
ATP + uridine = ADP + UMP sequential mechanism Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
Ehrlich ascites carcinoma cell
-
Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
283
-
-
Mus musculus

Storage Stability

Storage Stability Organism
-20°C, 50% glycerol, several months, no loss of activity Mus musculus
0°C, 8 weeks, 20% loss of activity Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 3-deazauridine
-
Mus musculus ADP + 3-deazauridine 5'-monophosphate
-
?
ATP + 5-fluorouridine
-
Mus musculus ADP + 5-fluorouridine 5'-monophosphate
-
?
ATP + 6-azauridine
-
Mus musculus ADP + 6-azauridine 5'-monophosphate
-
?
ATP + cytidine
-
Mus musculus ADP + CMP
-
?
ATP + uridine
-
Mus musculus ADP + UMP
-
?
ATP + uridine rate limiting enzyme of pyrimidine salvage pathway Mus musculus ADP + UMP
-
?
ATP + uridine rate-limiting enzyme in anabolism of uridine and cytidine Mus musculus ADP + UMP
-
?

Subunits

Subunits Comment Organism
? x * 31000, enzyme exists in multiple interconvertible oligomeric forms, SDS-PAGE Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
22
-
assay at Mus musculus
37
-
assay at Mus musculus