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Literature summary for 2.7.1.40 extracted from
- Dissimilar properties of pyruvate kinase from rabbit and hare muscle (2015), J. Evol. Biochem. Physiol., 51, 117-121.
No PubMed abstract available
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Lepus europaeus |  |
| ATP | - |
Oryctolagus cuniculus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + pyruvate | Oryctolagus cuniculus | - |
ADP + phosphoenolpyruvate | - |
? | |
| ATP + pyruvate | Lepus europaeus | - |
ADP + phosphoenolpyruvate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Lepus europaeus | - |
- |
- |
| Oryctolagus cuniculus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| ammonium sulfate precipitation and gel filtration | Oryctolagus cuniculus |
| ammonium sulfate precipitation and gel filtration | Lepus europaeus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| heart | - |
Oryctolagus cuniculus | - |
| heart | - |
Lepus europaeus | - |
| skeletal muscle | - |
Oryctolagus cuniculus | - |
| skeletal muscle | - |
Lepus europaeus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + pyruvate | - |
Oryctolagus cuniculus | ADP + phosphoenolpyruvate | - |
? | |
| ATP + pyruvate | - |
Lepus europaeus | ADP + phosphoenolpyruvate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| M1-PK | isoform | Oryctolagus cuniculus |
| M1-PK | isoform | Lepus europaeus |
| phosphoenolpyruvate: ADP phosphotransferase | - |
Oryctolagus cuniculus |
| phosphoenolpyruvate: ADP phosphotransferase | - |
Lepus europaeus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 44 | - |
- |
Oryctolagus cuniculus |
| 50 | - |
- |
Lepus europaeus |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 50 | 52 | 50% loss of activity after 10 min at 50-52°C | Oryctolagus cuniculus |
| 58 | 63 | 58% loss of activity after 10 min at 58-63°C | Lepus europaeus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
- |
Oryctolagus cuniculus |
| 7 | - |
- |
Lepus europaeus |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 1.3 | - |
enzyme from heart, at pH 7.4 and 30°C | Lepus europaeus | ATP | |
| 1.8 | - |
enzyme from skeletal muscle, at pH 7.4 and 30°C | Lepus europaeus | ATP | |
| 2 | - |
enzyme from heart, at pH 7.4 and 30°C | Oryctolagus cuniculus | ATP | |
| 5 | - |
enzyme from skeletal muscle, at pH 7.4 and 30°C | Oryctolagus cuniculus | ATP | |
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Release 2023.1 (January 2023)
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