Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | enzyme is not affected by fructose-1,6-bisphosphate and glucose 6-phosphate | Plasmodium falciparum |
Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Plasmodium falciparum |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Plasmodium falciparum | |
citrate | noncompetitive with respect to ADP | Plasmodium falciparum | |
pyridoxal 5'-phosphate | 1 mM | Plasmodium falciparum |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.12 | - |
ADP | - |
Plasmodium falciparum | |
0.19 | - |
phosphoenolpyruvate | - |
Plasmodium falciparum |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
80000 | - |
4 * 80000, SDS-PAGE | Plasmodium falciparum |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ADP + phosphoenolpyruvate | Plasmodium falciparum | the enzyme is expressed during the intraerythrocytic-stage of its developlental cycle that may play important metabolic roles during infection | ATP + pyruvate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Plasmodium falciparum | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ADP + phosphoenolpyruvate | the enzyme is expressed during the intraerythrocytic-stage of its developlental cycle that may play important metabolic roles during infection | Plasmodium falciparum | ATP + pyruvate | - |
? | |
ADP + phosphoenolpyruvate | important role of pyruvate kinase during malarial infection | Plasmodium falciparum | ATP + pyruvate | - |
? |
Subunits | Comment | Organism |
---|---|---|
homotetramer | 4 * 80000, SDS-PAGE | Plasmodium falciparum |
Synonyms | Comment | Organism |
---|---|---|
pfPyrK | - |
Plasmodium falciparum |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.8 | - |
citrate | with respect to ADP | Plasmodium falciparum |
Organism | Comment | pI Value Maximum | pI Value |
---|---|---|---|
Plasmodium falciparum | calculation from amino acid sequence | - |
7.5 |