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Literature summary for 2.7.1.40 extracted from

  • Chan, M.; Sim, T.S.
    Functional analysis, overexpression, and kinetic characterization of pyruvate kinase from Plasmodium falciparum (2005), Biochem. Biophys. Res. Commun., 326, 188-196.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information enzyme is not affected by fructose-1,6-bisphosphate and glucose 6-phosphate Plasmodium falciparum

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Plasmodium falciparum

Inhibitors

Inhibitors Comment Organism Structure
ATP
-
Plasmodium falciparum
citrate noncompetitive with respect to ADP Plasmodium falciparum
pyridoxal 5'-phosphate 1 mM Plasmodium falciparum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.12
-
ADP
-
Plasmodium falciparum
0.19
-
phosphoenolpyruvate
-
Plasmodium falciparum

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
80000
-
4 * 80000, SDS-PAGE Plasmodium falciparum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ADP + phosphoenolpyruvate Plasmodium falciparum the enzyme is expressed during the intraerythrocytic-stage of its developlental cycle that may play important metabolic roles during infection ATP + pyruvate
-
?

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADP + phosphoenolpyruvate the enzyme is expressed during the intraerythrocytic-stage of its developlental cycle that may play important metabolic roles during infection Plasmodium falciparum ATP + pyruvate
-
?
ADP + phosphoenolpyruvate important role of pyruvate kinase during malarial infection Plasmodium falciparum ATP + pyruvate
-
?

Subunits

Subunits Comment Organism
homotetramer 4 * 80000, SDS-PAGE Plasmodium falciparum

Synonyms

Synonyms Comment Organism
pfPyrK
-
Plasmodium falciparum

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.8
-
citrate with respect to ADP Plasmodium falciparum

pI Value

Organism Comment pI Value Maximum pI Value
Plasmodium falciparum calculation from amino acid sequence
-
7.5