Activating Compound | Comment | Organism | Structure |
---|---|---|---|
D-fructose 1,6-diphosphate | activation | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | - |
Rattus norvegicus | |
cysteine | fructose 1,6-diphosphate protects | Rattus norvegicus | |
D-serine | - |
Rattus norvegicus | |
L-alanine | fructose 1,6-diphosphate restores | Rattus norvegicus | |
L-phenylalanine | fructose 1,6-diphosphate protects | Rattus norvegicus | |
additional information | no phosphorylation | Rattus norvegicus | |
threonine | fructose 1,6-diphosphate protects | Rattus norvegicus | |
tyrosine | fructose 1,6-diphosphate partially protects | Rattus norvegicus | |
valine | fructose 1,6-diphosphate protects | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | kinetic parameters | Rattus norvegicus | |
0.082 | 0.4 | ADP | pH 7.1, 37°C | Rattus norvegicus | |
0.67 | - |
GDP | pH 7.1, 37°C | Rattus norvegicus | |
1.25 | - |
UDP | pH 7.1, 37°C | Rattus norvegicus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
K+ | - |
Rattus norvegicus | |
Mg2+ | - |
Rattus norvegicus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
224000 | - |
gel filtration | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
lung | M2-type isozyme | Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
1341 | - |
pH 7.1, 37°C | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ADP + phosphoenolpyruvate | best nucleoside diphosphate substrate | Rattus norvegicus | ATP + pyruvate | - |
? | |
CDP + phosphoenolpyruvate | less effective than ADP | Rattus norvegicus | CTP + pyruvate | - |
? | |
GDP + phosphoenolpyruvate | less effective than ADP | Rattus norvegicus | GTP + pyruvate | - |
? | |
IDP + phosphoenolpyruvate | less effective than ADP | Rattus norvegicus | ITP + pyruvate | - |
? | |
UDP + phosphoenolpyruvate | less effective than ADP | Rattus norvegicus | UTP + pyruvate | - |
? |
Subunits | Comment | Organism |
---|---|---|
tetramer | 4 * 62000-66000, SDS-PAGE | Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.5 | - |
- |
Rattus norvegicus |
Organism | Comment | pI Value Maximum | pI Value |
---|---|---|---|
Rattus norvegicus | - |
- |
5.8 |