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Literature summary for 2.7.1.40 extracted from
- Some kinetic properties of pyruvate kinase from Trypanosoma brucei (1992), Mol. Biochem. Parasitol., 50, 235-243.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| CO2 | activation, kinetics | Trypanosoma brucei |  |
| D-fructose 1,6-diphosphate | activation | Trypanosoma brucei | |
| D-fructose 1,6-diphosphate | slight | Trypanosoma brucei | |
| D-fructose 2,6-diphosphate | activation | Trypanosoma brucei | |
| D-fructose 2,6-diphosphate | best activator | Trypanosoma brucei | |
| D-fructose diphosphate | activation | Trypanosoma brucei | |
| D-glucose 1,6-diphosphate | slight activation | Trypanosoma brucei | |
| D-ribose 1-diphosphate 5-phosphate | activation, kinetics, much more effective than fructose 1,6-diphosphate or glucose 1,6-diphosphate | Trypanosoma brucei | |
| D-Ribulose 1,5-diphosphate | activation | Trypanosoma brucei | |
| D-Ribulose 1,5-diphosphate | kinetics | Trypanosoma brucei | |
| D-Ribulose 1,5-diphosphate | much more effective than fructose 1,6-diphosphate or glucose 1,6-diphosphate | Trypanosoma brucei | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | kinetic study | Trypanosoma brucei |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | requirement | Trypanosoma brucei | |
| Mg2+ | kinetics | Trypanosoma brucei | |
| Mn2+ | requirement | Trypanosoma brucei | |
| Mn2+ | kinetics | Trypanosoma brucei | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Trypanosoma brucei | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ADP + phosphoenolpyruvate | - |
Trypanosoma brucei | ATP + pyruvate | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| additional information | - |
effect of temperature on kinetic properties | Trypanosoma brucei |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| additional information | - |
effect of pH-values on kinetic properties | Trypanosoma brucei |
| 6 | - |
- |
Trypanosoma brucei |
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Release 2023.1 (January 2023)
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