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Literature summary for 2.7.1.4 extracted from

  • Andres-Hernando, A.; Li, N.; Cicerchi, C.; Inaba, S.; Chen, W.; Roncal-Jimenez, C.; Le, M.T.; Wempe, M.F.; Milagres, T.; Ishimoto, T.; Fini, M.; Nakagawa, T.; Johnson, R.J.; Lanaspa, M.A.
    Protective role of fructokinase blockade in the pathogenesis of acute kidney injury in mice (2017), Nat. Commun., 8, 14181 .
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
luteolin fructokinase inhibition protects mice from iAKI Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + D-fructose Mus musculus the first step in fructose metabolism is mediated by fructokinase ADP + D-fructose 6-phosphate
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Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + D-fructose
-
 Mus musculus ADP + D-fructose 6-phosphate
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 ?
ATP + D-fructose the first step in fructose metabolism is mediated by fructokinase Mus musculus ADP + D-fructose 6-phosphate
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 ?

General Information

General Information Comment Organism
metabolism role for fructokinase and endogenous fructose as mediators of acute renal disease. Fructokinase inhibition protects mice from ischaemic acute kidney injury Mus musculus