Application | Comment | Organism |
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medicine | wild-type mice that receive delayed hydration develop renal injury, with elevated serum creatinine, increased urinary neutrophil gelatinase-associated lipocalin, proximal tubular injury, and renal inflammation and fibrosis. This is associated with activation of the polyol pathway, with increased renal cortical sorbitol and fructose levels. Fructokinase-knockout mice with delayed hydration are protected from renal injury. Access to sufficient water during the dehydration period can protect mice from developing renal injury. Studies provide a potential mechanism for Mesoamerican nephropathy | Mus musculus |
Organism | UniProt | Comment | Textmining |
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Mus musculus | - |
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