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Literature summary for 2.7.1.4 extracted from
- Substrate specificity and product inhibition of different forms of fructokinases and hexokinases in developing potato tubers (1993), Planta, 190, 166-175.
No PubMed abstract available
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ADP | competitive to ATP | Solanum tuberosum |  |
| D-fructose | substrate inhibition | Solanum tuberosum | |
| D-fructose 6-phosphate | - |
Solanum tuberosum | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.025 | - |
ATP | FK 2, pH 8 | Solanum tuberosum | |
| 0.026 | - |
ATP | FK 1, pH 8 | Solanum tuberosum | |
| 0.064 | - |
D-fructose | FK 1, pH 8 | Solanum tuberosum | |
| 0.09 | - |
D-fructose | FK 2, pH 8 | Solanum tuberosum | |
| 0.1 | - |
D-fructose | FK 3, pH 8 | Solanum tuberosum | |
| 0.24 | - |
ATP | FK 3, pH 8 | Solanum tuberosum | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | maximal activation when total Mg2+ concentration is about 1.5 mM higher than the concentration of ATP | Solanum tuberosum | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + D-fructose | Solanum tuberosum | - |
ADP + D-fructose 6-phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Solanum tuberosum | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| FK1, FK2, FK3 | Solanum tuberosum |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| tuber | - |
Solanum tuberosum | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + D-fructose | - |
Solanum tuberosum | ADP + D-fructose 6-phosphate | - |
? | |
| ATP + D-fructose | higher affinity for ATP than for other NTPs | Solanum tuberosum | ADP + D-fructose 6-phosphate | - |
? | |
| CTP + D-fructose | - |
Solanum tuberosum | CDP + D-fructose 6-phosphate | - |
? | |
| GTP + D-fructose | - |
Solanum tuberosum | GDP + D-fructose 6-phosphate | - |
? | |
| additional information | no substrate: D-mannose | Solanum tuberosum | ? | - |
? | |
| additional information | no substrate: D-glucose | Solanum tuberosum | ? | - |
? | |
| UTP + D-fructose | - |
Solanum tuberosum | UDP + D-fructose 6-phosphate | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.8 | 8.5 | - |
Solanum tuberosum |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 6.7 | 9.3 | pH 6.7: about 50% of activity maximum, pH 9.3: about 60% of activity maximum | Solanum tuberosum |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1.3 | - |
D-fructose 6-phosphate | FK 1, pH 8 | Solanum tuberosum | |
| 5.7 | - |
D-fructose | FK 1, pH 8 | Solanum tuberosum | |
| 6 | - |
D-fructose | FK 2, pH 8 | Solanum tuberosum | |
| 21 | - |
D-fructose | FK 3, pH 8 | Solanum tuberosum | |
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