Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5'-adenylylimidodiphosphate | - |
Escherichia coli | |
L-alpha-aminobutyric acid | - |
Escherichia coli | |
L-aspartate semialdehyde | mixed inhibition versus L-homoserine and ATP | Escherichia coli | |
L-homoserine | above 0.75 mM | Escherichia coli |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.15 | - |
L-homoserine | pH 7.8 | Escherichia coli | |
0.58 | - |
L-aspartate semialdehyde | pH 7.8 | Escherichia coli | |
3.8 | - |
4-hydroxynorvaline | pH 7.8 | Escherichia coli |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Escherichia coli |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
ATP + L-homoserine = ADP + O-phospho-L-homoserine | ordered random mechanism with ATP preferentially binding before L-homoserine | Escherichia coli |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 4-hydroxynorvaline | 0.3% of the activity with L-homoserine | Escherichia coli | ADP + 4-phospho-L-norvaline | - |
? | |
ATP + L-aspartate 4-semialdehyde | 10% of the activity with L-homoserine | Escherichia coli | ? | - |
? | |
ATP + L-homoserine | - |
Escherichia coli | ADP + O-phospho-L-homoserine | - |
? |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
50 | - |
stable up to in absence of ligands | Escherichia coli |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.15 | - |
L-alpha-aminobutyric acid | - |
Escherichia coli | |
0.9 | - |
5'-adenylylimidodiphosphate | pH 7.4 | Escherichia coli | |
2 | - |
L-homoserine | pH 7.6 | Escherichia coli |