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Literature summary for 2.7.1.36 extracted from

  • Qiu, Y.; Li, D.
    Bifunctional inhibitors of mevalonate kinase and mevalonate 5-diphosphate decarboxylase (2006), Org. Lett., 8, 1013-1016.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(3R),(5S)-P'-geranyl 3,5,8-trihydroxy-3-methyloctanate 8-diphosphate
-
Rattus norvegicus
(3S),(5R)-P'-geranyl 3,5,8-trihydroxy-3-methyloctanate 8-diphosphate
-
Rattus norvegicus
8-[[hydroxy(phosphonooxy)phosphoryl]oxy]octanoic acid
-
Rattus norvegicus
geranyl diphosphate
-
Rattus norvegicus
mevalonate 5-diphosphate
-
Rattus norvegicus
additional information organic synthesis of bisubstrate analogues, organic synthesis and biological characterization of bifunctional molecules, which can inhibit both MVK and mevalonate 5-diphosphate decarboxylase Rattus norvegicus
P'-geranyl 3,5,7-trihydroxy-3-methylheptanate 7-diphosphate
-
Rattus norvegicus
P'-geranyl 3,5,8-trihydroxy-3-methyloctanate 8-diphosphate
-
Rattus norvegicus
P'-geranyl 3,5,9-trihydroxy-3-methylnonanate 9-diphosphate
-
Rattus norvegicus
P'-geranyl octanate 8-diphosphate
-
Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + (R)-mevalonate Rattus norvegicus a step in the mevalonate pathway, overview ADP + (R)-5-phosphomevalonate
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + (R)-mevalonate
-
Rattus norvegicus ADP + (R)-5-phosphomevalonate
-
?
ATP + (R)-mevalonate a step in the mevalonate pathway, overview Rattus norvegicus ADP + (R)-5-phosphomevalonate
-
?

Synonyms

Synonyms Comment Organism
MVK
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0025
-
pH 7.0, 30°C Rattus norvegicus (3S),(5R)-P'-geranyl 3,5,8-trihydroxy-3-methyloctanate 8-diphosphate
0.0038
-
pH 7.0, 30°C Rattus norvegicus P'-geranyl 3,5,8-trihydroxy-3-methyloctanate 8-diphosphate
0.0039
-
pH 7.0, 30°C Rattus norvegicus P'-geranyl 3,5,9-trihydroxy-3-methylnonanate 9-diphosphate
0.005
-
-
Rattus norvegicus geranyl diphosphate
0.0055
-
pH 7.0, 30°C Rattus norvegicus P'-geranyl octanate 8-diphosphate
0.0075
-
pH 7.0, 30°C Rattus norvegicus (3R),(5S)-P'-geranyl 3,5,8-trihydroxy-3-methyloctanate 8-diphosphate
0.008
-
pH 7.0, 30°C Rattus norvegicus P'-geranyl 3,5,7-trihydroxy-3-methylheptanate 7-diphosphate
0.18
-
-
Rattus norvegicus mevalonate 5-diphosphate
0.45
-
pH 7.0, 30°C Rattus norvegicus 8-[[hydroxy(phosphonooxy)phosphoryl]oxy]octanoic acid