Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(3R),(5S)-P'-geranyl 3,5,8-trihydroxy-3-methyloctanate 8-diphosphate | - |
Rattus norvegicus | |
(3S),(5R)-P'-geranyl 3,5,8-trihydroxy-3-methyloctanate 8-diphosphate | - |
Rattus norvegicus | |
8-[[hydroxy(phosphonooxy)phosphoryl]oxy]octanoic acid | - |
Rattus norvegicus | |
geranyl diphosphate | - |
Rattus norvegicus | |
mevalonate 5-diphosphate | - |
Rattus norvegicus | |
additional information | organic synthesis of bisubstrate analogues, organic synthesis and biological characterization of bifunctional molecules, which can inhibit both MVK and mevalonate 5-diphosphate decarboxylase | Rattus norvegicus | |
P'-geranyl 3,5,7-trihydroxy-3-methylheptanate 7-diphosphate | - |
Rattus norvegicus | |
P'-geranyl 3,5,8-trihydroxy-3-methyloctanate 8-diphosphate | - |
Rattus norvegicus | |
P'-geranyl 3,5,9-trihydroxy-3-methylnonanate 9-diphosphate | - |
Rattus norvegicus | |
P'-geranyl octanate 8-diphosphate | - |
Rattus norvegicus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + (R)-mevalonate | Rattus norvegicus | a step in the mevalonate pathway, overview | ADP + (R)-5-phosphomevalonate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + (R)-mevalonate | - |
Rattus norvegicus | ADP + (R)-5-phosphomevalonate | - |
? | |
ATP + (R)-mevalonate | a step in the mevalonate pathway, overview | Rattus norvegicus | ADP + (R)-5-phosphomevalonate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MVK | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0025 | - |
pH 7.0, 30°C | Rattus norvegicus | (3S),(5R)-P'-geranyl 3,5,8-trihydroxy-3-methyloctanate 8-diphosphate | |
0.0038 | - |
pH 7.0, 30°C | Rattus norvegicus | P'-geranyl 3,5,8-trihydroxy-3-methyloctanate 8-diphosphate | |
0.0039 | - |
pH 7.0, 30°C | Rattus norvegicus | P'-geranyl 3,5,9-trihydroxy-3-methylnonanate 9-diphosphate | |
0.005 | - |
- |
Rattus norvegicus | geranyl diphosphate | |
0.0055 | - |
pH 7.0, 30°C | Rattus norvegicus | P'-geranyl octanate 8-diphosphate | |
0.0075 | - |
pH 7.0, 30°C | Rattus norvegicus | (3R),(5S)-P'-geranyl 3,5,8-trihydroxy-3-methyloctanate 8-diphosphate | |
0.008 | - |
pH 7.0, 30°C | Rattus norvegicus | P'-geranyl 3,5,7-trihydroxy-3-methylheptanate 7-diphosphate | |
0.18 | - |
- |
Rattus norvegicus | mevalonate 5-diphosphate | |
0.45 | - |
pH 7.0, 30°C | Rattus norvegicus | 8-[[hydroxy(phosphonooxy)phosphoryl]oxy]octanoic acid |