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Literature summary for 2.7.1.35 extracted from

  • Gandhi, A.K.; Desai, J.V.; Ghatge, M.S.; di Salvo, M.L.; Di Biase, S.; Danso-Danquah, R.; Musayev, F.N.; Contestabile, R.; Schirch, V.; Safo, M.K.
    Crystal structures of human pyridoxal kinase in complex with the neurotoxins, ginkgotoxin and theophylline: insights into pyridoxal kinase inhibition (2012), PLoS ONE, 7, e40954.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.35

Crystallization (Commentary)

Crystallization (Comment) Organism
in complex with ginkgotoxin and theophylline, hanging drop vapor diffusion method, using 48-50% (w/v) 2-methyl-1,3 propanediol as precipitant, at 22°C Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Caffeine 21% inhibition at 0.1 mM Homo sapiens
enprofylline 33% inhibition at 0.1 mM Homo sapiens
ginkgotoxin i.e. 4'-O-methylpyridoxine, complete inhibition at 0.1 mM Homo sapiens
lamotrigine 45% inhibition at 0.1 mM Homo sapiens
Theobromine 22% inhibition at 0.1 mM Homo sapiens
theophylline 60% inhibition at 0.1 mM Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O00764
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + pyridoxal
-
 Homo sapiens ADP + pyridoxal 5'-phosphate
-
 ir
ATP + pyridoxamine
-
 Homo sapiens ADP + pyridoxamine 5'-phosphate
-
 ir

Synonyms

Synonyms Comment Organism
PL kinase
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.003
-
 ginkgotoxin in 20 mM sodium BES buffer, pH 7.2, at 37°C Homo sapiens
0.05
-
 theophylline in 20 mM sodium BES buffer, pH 7.2, at 37°C Homo sapiens
0.056
-
 lamotrigine in 20 mM sodium BES buffer, pH 7.2, at 37°C Homo sapiens
0.228
-
 enprofylline in 20 mM sodium BES buffer, pH 7.2, at 37°C Homo sapiens