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Literature summary for 2.7.1.35 extracted from

  • Chern, C.J.; Beutler, E.
    Purification and characterization of human erythrocyte pyridoxine kinase (1975), Clin. Chim. Acta, 61, 353-365.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
NH4+ slightly less effective in activation than K+ Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
4-deoxypyridoxine
-
Homo sapiens
Na+
-
Homo sapiens
pyridoxal
-
Homo sapiens
pyridoxamine
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0057
-
pyridoxine
-
Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Co2+ cations activate in decreasing order of efficiency: Co2+, Mn2+, Mg2+, Zn2+, Cu2+, Ni2+, Fe2+ Homo sapiens
Cu2+ cations activate in decreasing order of efficiency: Co2+, Mn2+, Mg2+, Zn2+, Cu2+, Ni2+, Fe2+ Homo sapiens
Fe2+ cations activate in decreaseing order of efficiency: Co2+, Mn2+, Mg2+, Zn2+, Cu2+, Ni2+, Fe2+ Homo sapiens
K+ most effective activator of the monovalent cations Homo sapiens
Mg2+ cations activate in decreasing order of efficiency: Co2+, Mn2+, Mg2+, Zn2+, Cu2+, Ni2+, Fe2+ Homo sapiens
Mn2+ cations activate in decreasing order of efficiency: Co2+, Mn2+, Mg2+, Zn2+, Cu2+, Ni2+, Fe2+ Homo sapiens
Ni2+ cations activate in decreasing order of efficiency: Co2+, Mn2+, Mg2+, Zn2+, Cu2+, Ni2+, Fe2+ Homo sapiens
Zn2+ cations activate in decreasing order of efficiency: Co2+, Mn2+, Mg2+, Zn2+, Cu2+, Ni2+, Fe2+ Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
65000
-
gel filtration Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + pyridoxal
-
Homo sapiens ADP + pyridoxal 5'-phosphate
-
?
ATP + pyridoxine
-
Homo sapiens ADP + pyridoxine 5'-phosphate
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.5
-
-
Homo sapiens