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Literature summary for 2.7.1.35 extracted from
- Pyridoxal phosphokinases. I. Assay, distribution, purification, and properties (1961), J. Biol. Chem., 236, 2076-2084.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| AMP | - |
Rattus norvegicus |  |
| K+ | at high concentrations | Bos taurus | |
| Li+ | at high concentrations | Bos taurus | |
| Na+ | at high concentrations | Bos taurus | |
| Na+ | - |
Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| soluble | - |
Rattus norvegicus | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Co2+ | - |
Homo sapiens | |
| Co2+ | 0.2 mM, partial activation | Saccharomyces cerevisiae | |
| Cu2+ | - |
Homo sapiens | |
| Cu2+ | 0.2 mM, partial activation | Meleagris gallopavo | |
| K+ | - |
Homo sapiens | |
| K+ | activates in presence of optimal concentrations of Zn2+ | Bos taurus | |
| Mg2+ | - |
Homo sapiens | |
| Mg2+ | 0.2 mM, activates | Meleagris gallopavo | |
| Mg2+ | 0.2 mM, activates | Rattus norvegicus | |
| Mn2+ | - |
Homo sapiens | |
| Mn2+ | 0.2 mM, partial activation | Meleagris gallopavo | |
| Mn2+ | 0.2 mM, partial activation | Rattus norvegicus | |
| Mn2+ | 0.2 mM, partial activation | Saccharomyces cerevisiae | |
| Ni2+ | - |
Homo sapiens | |
| Ni2+ | 0.2 mM, partial activation | Saccharomyces cerevisiae | |
| Zn2+ | - |
Homo sapiens | |
| Zn2+ | 0.2 mM, activates | Meleagris gallopavo | |
| Zn2+ | 0.2 mM, activates | Rattus norvegicus | |
| Zn2+ | 0.2 mM, activates | Saccharomyces cerevisiae | |
| Zn2+ | half-maximal activation at 0.01 mM | Saccharomyces cerevisiae | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Enterococcus faecalis | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Lacticaseibacillus casei | - |
- |
- |
| Lactobacillus delbrueckii subsp. bulgaricus | - |
- |
- |
| Meleagris gallopavo | - |
- |
- |
| Mus musculus | - |
- |
- |
| Neurospora crassa | - |
- |
- |
| Oryctolagus cuniculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
| Saccharomyces cerevisiae | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Saccharomyces cerevisiae |
- |
Enterococcus faecalis |
- |
Lacticaseibacillus casei |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Meleagris gallopavo | - |
| brain | - |
Homo sapiens | - |
| brain | - |
Rattus norvegicus | - |
| brain | - |
Bos taurus | - |
| kidney | - |
Rattus norvegicus | - |
| liver | - |
Rattus norvegicus | - |
| muscle | weak activity | Rattus norvegicus | - |
| mycelium | - |
Saccharomyces cerevisiae | - |
| spleen | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.00135 | - |
- |
Lacticaseibacillus casei |
| 0.0036 | - |
- |
Enterococcus faecalis |
| 0.004 | - |
brain enzyme | Rattus norvegicus |
| 0.0125 | - |
- |
Bos taurus |
| 0.0125 | - |
liver enzyme | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + pyridoxal | - |
Meleagris gallopavo | ADP + pyridoxal 5'-phosphate | - |
? | |
| ATP + pyridoxal | - |
Mus musculus | ADP + pyridoxal 5'-phosphate | - |
? | |
| ATP + pyridoxal | - |
Homo sapiens | ADP + pyridoxal 5'-phosphate | - |
? | |
| ATP + pyridoxal | - |
Rattus norvegicus | ADP + pyridoxal 5'-phosphate | - |
? | |
| ATP + pyridoxal | - |
Saccharomyces cerevisiae | ADP + pyridoxal 5'-phosphate | - |
? | |
| ATP + pyridoxal | - |
Bos taurus | ADP + pyridoxal 5'-phosphate | - |
? | |
| ATP + pyridoxal | - |
Oryctolagus cuniculus | ADP + pyridoxal 5'-phosphate | - |
? | |
| ATP + pyridoxal | - |
Neurospora crassa | ADP + pyridoxal 5'-phosphate | - |
? | |
| ATP + pyridoxal | - |
Enterococcus faecalis | ADP + pyridoxal 5'-phosphate | - |
? | |
| ATP + pyridoxal | - |
Lacticaseibacillus casei | ADP + pyridoxal 5'-phosphate | - |
? | |
| ATP + pyridoxal | - |
Lactobacillus delbrueckii subsp. bulgaricus | ADP + pyridoxal 5'-phosphate | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 40 | - |
Zn2+ as activating anion | Homo sapiens |
| 50 | - |
Mg2+ as activating anion | Homo sapiens |
| 55 | - |
- |
Rattus norvegicus |
| 55 | - |
- |
Lacticaseibacillus casei |
| 63 | - |
- |
Enterococcus faecalis |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 4.5 | - |
- |
Lactobacillus delbrueckii subsp. bulgaricus |
| 5 | - |
- |
Lacticaseibacillus casei |
| 5.2 | - |
- |
Enterococcus faecalis |
| 5.7 | - |
- |
Rattus norvegicus |
| 5.8 | - |
- |
Saccharomyces cerevisiae |
| 6.5 | - |
- |
Saccharomyces cerevisiae |
| 6.8 | - |
- |
Saccharomyces cerevisiae |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 4.7 | 5.3 | pH 4.7: about 60% of maximal activity, pH 5.3: about 40% of maximal activity | Lacticaseibacillus casei |
| 5 | 5.7 | pH 5.0: about 90% of maximal activity, pH 5.7: about 45% of maximal activity | Enterococcus faecalis |
| 6 | 7 | pH 6.0: about 50% of maximal activity, pH 7.0: about 50% of maximal activity | Neurospora crassa |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.06 | - |
AMP | - |
Rattus norvegicus | |
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