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Literature summary for 2.7.1.33 extracted from

  • Leonardi, R.; Rehg, J.E.; Rock, C.O.; Jackowski, S.
    Pantothenate kinase 1 is required to support the metabolic transition from the fed to the fasted state (2010), PLoS ONE, 5, e11107.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.33

Application

Application Comment Organism
medicine the enzyme is a suitable target for therapeutic intervention in metabolic disorders that feature hyperglycemia and hypertriglyceridemia Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + (R)-pantothenate
-
 Mus musculus ADP + (R)-4'-phosphopantothenate
-
 ?

Synonyms

Synonyms Comment Organism
PanK1 isoform Mus musculus
pantothenate kinase 1
-
 Mus musculus

General Information

General Information Comment Organism
malfunction the elimination of PanK1 reduces hepatic CoA levels. Pank1-deficient mice become hypoglycemic during a fast due to impaired gluconeogenesis Mus musculus
physiological function pantothenate kinase 1 is required to support the metabolic transition from the fed to the fasted state Mus musculus